|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A BRAF mutation can be reliably detected in cells aspirated from a thyroid nodule suggesting a role for this marker in the preoperative evaluation of thyroid nodules.
|
15102681 |
2004 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that BRAF mutations are rather rare in solitary cold adenomas and adenomatous nodules and do not explain the molecular etiology of ras mutation-negative cold thyroid nodules.
|
15186612 |
2004 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our study suggests that BRAF mutations are rather rare in solitary cold adenomas and adenomatous nodules and do not explain the molecular etiology of ras mutation-negative cold thyroid nodules.
|
15186612 |
2004 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the role of pre-operative detection of BRAF(V600E) mutation in the FNAB specimens of thyroid nodules in a BRAF(V600E) mutation-prevalent geographical area.
|
17054470 |
2006 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate BRAF(V600E) mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB's usefulness in preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET/PTC1 and RET/PTC3 rearrangements obtained from ex vivo thyroid nodules.
|
17727338 |
2007 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of RET/PTC, TRK and BRAF(V600E) in FNAB specimens is proposed as a diagnostic adjunctive tool in the evaluation of thyroid nodules with suspicious cytological findings.
|
17381488 |
2007 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.
|
17641411 |
2007 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detecting BRAF mutation by pyrosequencing is more sensitive, faster, and less expensive than direct DNA sequencing and is proposed as an adjunct diagnostic tool in evaluating thyroid nodules of indeterminate cytology.
|
18382358 |
2008 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
US-guided fine-needle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery.
|
19710001 |
2009 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four hundred seventeen patients with 455 thyroid nodules were enrolled and had genetic testing for common somatic mutations (BRAF, NRAS, KRAS) and gene rearrangements (RET/PTC1, RET/PTC3, RAS, TRK1) by PCR and direct sequencing and by nested PCR, respectively.
|
20703476 |
2010 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of BRAF mutations in thyroid nodules by allele-specific PCR using a dual priming oligonucleotide system.
|
20395530 |
2010 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed at evaluating the effective indication and method of BRAF(V600E) mutation analysis of aspiration specimens according to the US features of thyroid nodules in a BRAF(V600E) mutation-prevalent area.
|
20187782 |
2010 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whenever necessary BRAF testing may also be performed on the residual samples of thyroid nodules, without interfering with routine cytology.
|
19693938 |
2010 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
One hundred seventy-four consecutive patients undergoing thyroid surgery were submitted to FNAC (on 235 thyroid nodules) that was used for cytology and molecular analysis of BRAF, RAS, RET, TRK, and PPRgamma mutations.
|
20130073 |
2010 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) positivity was a useful marker at thyroid nodules with "suspicious for papillary thyroid carcinoma" or "inadequate" cytological result.
|
19672964 |
2010 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of papillary thyroid carcinoma by analysis of BRAF and RET/PTC1 mutations in fine-needle aspiration biopsies of thyroid nodules.
|
20652698 |
2010 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration.
|
20945104 |
2011 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF analysis by fine needle aspiration biopsy of thyroid nodules improves preoperative identification of papillary thyroid carcinoma and represents a prognostic factor. A mono-institutional experience.
|
21175381 |
2011 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The application of BRAF(V600E) mutation analysis in US-guided FNAB can improve the diagnostic accuracy of thyroid nodules.
|
21707687 |
2011 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that performing BRAF(V600E) mutation analysis on the fine-needle aspiration biopsy specimens was of great help to make a therapeutic decision for thyroid nodules when the fine-needle aspiration biopsy results were equivocal.
|
21239517 |
2011 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical implication of highly sensitive detection of the BRAF V600E mutation in fine-needle aspirations of thyroid nodules: a comparative analysis of three molecular assays in 4585 consecutive cases in a BRAF V600E mutation-prevalent area.
|
22500044 |
2012 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF mutational analysis is commonly used to assess the malignancy of thyroid nodules but unfortunately it still leaves indeterminate diagnoses.
|
22233760 |
2012 |
|
Thyroid Nodule
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF molecular testing holds promise as a possible diagnostic tool for indeterminate FNAs, and as a determinant for planning initial clinical management of thyroid nodules.
|
22123232 |
2012 |
|
Thyroid Nodule
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF(T1799A) mutation improves the diagnosis of PTC on FNAB, mainly because of the detection of cytopathology false-negatives, and it can be helpful in the routine analysis of thyroid nodules, especially in clinical settings with moderate sensitivity to detect PTC on FNAB.
|
22504197 |
2012 |
|
Thyroid Nodule
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We concluded that BRAF mRNA expression may help to identify PTC among thyroid nodules independently of the presence of BRAFV600E mutation.
|
22770943 |
2012 |