Disease: Cutaneous Melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site. 19383313 2008
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Absence of BRAF gene mutation in non-melanoma skin tumors. 16687919 2006
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE We sought to further evaluate the prognostic value of BRAF mutations in localized cutaneous melanoma. 24388723 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Correction to: Dynamic and unpredictable changes in mutant allele fractions of BRAF and NRAS during visceral progression of cutaneous malignant melanoma. 31464610 2019
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site. 21324100 2011
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The present study investigated the BRAF V600E mutation frequency and its clinical implications in a group of 77 primary cutaneous melanoma patients treated in a cancer reference center in Brazil. 24535907 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues. 24858900 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Herein, we report the case of a 65-year-old man with papillary TC and cutaneous malignant melanoma metastatic to masseter muscle, both characterized by BRAF mutation. 24574369 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE We obtained blood and tissue samples from a patient diagnosed with a BRAF(V600E)-mutant cutaneous melanoma that was treated with vemurafenib and achieved a near-complete response. 23948972 2013
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE As the current knowledge about pathogenesis, clinical and genetic features of cutaneous melanoma is not very clear, we aim to use bioinformatics to identify the potential key genes involved in the expression and mutation status of BRAF. 30925905 2019
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE BRAF inhibitors target the BRAF-V600E/K mutated kinase, the driver mutation found in 50% of cutaneous melanoma. 30429474 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. 21166657 2011
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Recently, a high incidence of activating mutations in the kinase domain of the BRAF gene has been reported in malignant melanoma of the skin. 15588860 2005
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE NRAS and BRAF mutations in cutaneous melanoma and the association with MC1R genotype: findings from Spanish and Austrian populations. 23096702 2013
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The purpose of this study was to determine whether the T1799A BRAF mutation found in cutaneous melanoma is also present in conjunctival melanoma. 15277467 2004
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The most common recurring mutation in cutaneous melanoma is the prooncogenic BRAF V600E mutation that drives melanoma cell proliferation. 23174497 2012
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib. 25036880 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE BRAF is the most frequently mutated gene in skin melanoma. 30347273 2018
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE Recent molecular studies have identified recurrent BRAF mutations in both cutaneous melanoma and thyroid malignancies. 16049985 2006
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The classical V600E BRAF mutation was not found; instead a novel V600L was observed suggesting that the oncogenic event in OMM is different from that in skin melanoma. 21750866 2011
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE A set of 250 probes representing 209 genes that were significantly (raw P< or =0.001) associated with BRAF mutation status was identified and 17 of these were previously shown to be implicated in cutaneous melanoma progression or pigmentation pathway-associated genes driven by the microphthalmia transcription factor (MITF). 19383316 2008
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy. 29310328 2017
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. 15928660 2005
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE We investigated 132 cases of primary cutaneous melanoma in patients aged between 18 and 30 years with emphasis on clinical characteristics, pathologic features, and molecular evaluation of mutation in the BRAF gene (BRAF(V600E)). 24471189 2014
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.500 GeneticVariation disease BEFREE To identify the dermoscopic features associated with BRAF mutation in cutaneous melanoma and to evaluate a model capable of predicting BRAF mutations on the basis of dermoscopic and clinicopathologic features that are easily accessible in normal clinical practice. 29307636 2018