Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.
|
31842975 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A preventive potential of high calcium intake against colorectal cancer has been indicated for distal colon cancer, which is inversely associated with high-level CpG island methylator phenotype (CIMP), high-level microsatellite instability (MSI), and BRAF and PIK3CA mutations.
|
30963391 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The kinetics of ctDNA derived from each cancer type were monitored targeting BRAF V600R (melanoma) and KRAS G13D (colon cancer), specifically reflected the status of the patient's tumours.
|
31727009 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated whether combination of 5-FU and a MEK inhibitor had treatment sequence-dependent synergistic effects in KRAS or BRAF mutant colon cancer models.
|
30579838 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The subgroup of colon cancer (CRC) characterized by mutation in the BRAF gene and high mutation rate in the genomic DNA sequence, known as the microsatellite instability (MSI) phenotype, accounts for roughly 10% of the patients and derives from polyps with a serrated morphology.
|
30623363 |
2019 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, tetrathiomolybdate treatment was also effective in reducing the clonogenic potential of colon cancer BRAF<sup>V600E</sup> cells resistant to BRAF pharmacological inhibition.
|
31083627 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, it is demonstrated that KRAS and BRAF mutations induce anoikis resistance in colon cancer (Caco‑2) cells.
|
31545494 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemistry with Anti-BRAF V600E (VE1) Mouse Monoclonal Antibody is a Sensitive Method for Detection of the BRAF V600E Mutation in Colon Cancer: Evaluation of 120 Cases with and without KRAS Mutation and Literature Review.
|
29127628 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report.
|
31185985 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results highlight the need to evaluate the action of glucocorticoid on cancer progression in melanoma, thyroid and colon carcinoma in which B-RAF-V600E is a frequent oncogene, and cancers in which evasion from senescence has been shown.
|
31371485 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A colon cancer cell line with RNF43-G659Vfs*41 and BRAF-V600E mutations was sensitive to activation of Wnt/β-catenin signaling.
|
31811196 |
2019 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serine/threonine kinase B-Raf proto-oncogene (BRAF) mutant colon cancer has a poor prognosis and there is an absence of targeted treatments for this subtype.
|
30396937 |
2018 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fisher's exact test showed that only two detected mutations at BRAF (V600E) and PIK3CA (E542K) were significantly positively correlated with right-sided colon cancer.
|
29556349 |
2018 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A higher average number of mutations were observed in right versus left colorectal cancer (P < .01), with 13 of 14 BRAF mutations located in right colon cancer.
|
29128266 |
2018 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Colon carcinoma BRAF V600E HT29 cells exhibited poor response to radiation compared to BRAF wild-type COLO320 and HCT116 cells.
|
29663854 |
2018 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the prognostic and predictive value of PTL according to BRAF, RAS, and MSI status in patients with stage III CC receiving adjuvant treatment with FOLFOX (folinic acid [leucovorin calcium], fluorouracil, and oxaliplatin) with or without cetuximab.
|
29167892 |
2018 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although <i>BRAF</i>-directed treatments have yielded clinical benefit in a subset of tumor types, such as melanoma, thyroid cancer, and lung cancer, BRAF inhibition fails to confer a clinical benefit in colon cancer.
|
30181415 |
2018 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTL does not seem to clearly influence disease-free survival (DFS) in localised colon cancer even though the opposite prognostic value of RS tumors on DFS depending on RAS/BRAF mutational status has been recently suggested in these patients.
|
29790124 |
2018 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition.
|
29167314 |
2018 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among patients with non-MSI-high cancer, BRAF mutation status emerged as a distinct marker with higher connectivity in the network of proximal colon cancer, but not in distal colorectal cancer.
|
28623901 |
2017 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the influence of BRAF and KRAS mutation status on the association between aspirin use and overall survival after colon cancer diagnosis.
|
28125730 |
2017 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To date, identification of HER2 expression in gastric adenocarcinoma and KRAS, NRAS and BRAF mutations in colon cancer have proved essential for treatment decisions.
|
28067073 |
2017 |
Colon Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings illustrate the utility of non-invasive PET imaging measures of glutamine uptake to selectively predict response to BRAF-targeted therapy in colon cancer and may suggest further opportunities to inform colon cancer clinical trials using targeted therapies against MAPK activation.
|
27770401 |
2017 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Activating BRAF mutations promote constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway and are common in a variety of human malignancies, including melanoma and colon cancer.
|
27321184 |
2017 |
Colon Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Complex <b>1</b> has an outstanding inhibitory effect against BRAF-mutant colon carcinoma and hepatocarcinoma cell growth; <b>1</b> and <b>2</b> are both more active than the free ligand and have the capacity to trigger early apoptotic processes.
|
28358339 |
2017 |