|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
Predictors of ILD progression were elevated anti-RNP titre [hazard ratio (HR) 1.5, 95% CI: 1.1, 2.0; P = 0.008], presence of anti-ro52 antibodies (HR = 3.5, 95% CI: 1.2, 10.2; P = 0.023), absence of arthritis (HR = 0.2, 95% CI: 0.1, 0.6; P = 0.004) and male gender (HR = 4.0, 95% CI: 1.4, 11.5; P = 0.011) after age and baseline disease adjustments.
|
28379478 |
2018 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
There is a suggestion of anti-Ro52 being associated with more clinical and laboratory markers of disease; however, marked disagreements occur about its association with various clinical entities such as interstitial lung disease and Raynaud's phenomena.
|
28417151 |
2017 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
Xerostomia (OR = 3.960), ILD (OR = 6.210), and anti-SSA (OR = 24.640) were independent predictors of RA overlapping with SS.
|
29670135 |
2018 |
|
Lung Diseases, Interstitial
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We then examined the titer of Ro52-autoAbs in the sera of 192 CTD patients and assessed the relationship between the serum levels of Ro52-autoAbs that were reactive to PEP08 peptide and the clinical morbidity and severity of ILD.
|
29989658 |
2018 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
For distinguishing DM/PM with ILD from DM/PM without ILD, the sensitivity, specificity, and PPV for anti-MDA5 were 45.57, 100.00, and 100.00%, respectively, and for anti-Ro-52 were 60.76, 73.91, and 80.00%, respectively.
|
30616054 |
2019 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-Ro-52 and anti-Scl-70 had increased values for predicting ILD in SSc patients, while anti-Ro-52 had increased values for predicting PAH in SSc patients.
|
30685360 |
2019 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
After controlling for the presence of myositis-specific autoantibodies, anti-Ro52 autoantibodies were associated with the presence of ILD (36% vs 4%, p<0.001).
|
31018961 |
2019 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
The estimated high-resolution computed tomography (HRCT) patterns of the five patients showed organizing pneumonia (OP) while RP-ILD patients without Ro-52 antibodies and non-RP-ILD patients with isolated Ro-52 antibodies mainly showed non-specific interstitial pneumonia (NSIP) patterns(P < 0.05).
|
31344662 |
2019 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-Ro52 positivity was more prevalent in RP-ILD.
|
31375890 |
2019 |
|
Lung Diseases, Interstitial
|
0.100 |
Biomarker
|
group |
BEFREE |
The majority of patients with ILD and anti-Ro52 had no established connective tissue disease (78%), and one-third had no rheumatologic symptoms.
|
31718649 |
2019 |