TRIM21, tripartite motif containing 21, 6737

N. diseases: 229; N. variants: 1
Disease: Malignant neoplasm of breast ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 GeneticVariation disease BEFREE R64Q, a breast cancer-associated TRIM21 mutation, abolishes the interaction between TRIM21 and Snail, and the TRIM21-mediated ubiquitination and degradation of Snail. 31622717 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 AlteredExpression disease BEFREE High-level expression of TRIM21 is associated with longer overall survival in breast cancer. 30502437 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 Biomarker disease BEFREE South Africa's public healthcare system is better equipped to manage breast cancer than most other SSA countries, but survival rates are unknown. 29306221 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 AlteredExpression disease BEFREE Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif-containing 21. 29511085 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 AlteredExpression disease BEFREE Low TRIM21 expression was correlated with poor overall and disease-free survival in two independent cohorts containing 1,219 patients with breast cancer. 30288100 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 AlteredExpression disease BEFREE Hormonal depletion of the human breast cancer cell line MCF-7 showed decreased levels of SS-A/Ro mRNA and protein, and the addition of estradiol led to an increase in SS-A/Ro expression. 8823369 1996