TRIM21, tripartite motif containing 21, 6737

N. diseases: 229; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Six formalin-fixed paraffin-embedded CRCs developed within SSA/P were profiled for the immunohistochemical expression of MMR proteins (MLH1, MSH2, MSH6, PMS2, and Ep-CAM), p16, and β-catenin. 30738693 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE SSA/P and colorectal cancer may not be suitable for CSP adoption. 29516270 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Sessile serrated adenoma/polyps (SSA/P) are premalignant lesions of colorectal cancer that are difficult to distinguish histologically from hyperplastic polyps (HP) of minimal to no malignant potential. 27705923 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE It has been suggested that SSA/P in the proximal colon are a precursor lesion of pathogenesis of colorectal cancer and are characterized by BRAF mutation and a CpG island methylator phenotype with or without microsatellite instability. 27376251 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE The relative abundance of Fusobacteria did not differ significantly between the TA and SSA/P groups (4.3% and 1.9%, P = 0.739) but was higher in the CRC group (33.8%) than in the TA or SSA/P group, respectively (TA vs. CRC, P = 0.002, false discovery rate [FDR] = 0.023; SSA/P vs. CRC, P < 0.001, FDR = 0.001). 27125587 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE To clarify molecular alterations in serrated pathway of colorectal cancer (CRC), we performed epigenetic and genetic analyses in sessile serrated adenoma/polyps (SSA/P), traditional serrated adenomas (TSAs) and high-methylation CRC. 26510091 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Recurrent SSA/P or adenomas occurred in 68% of patients at surveillance colonoscopy.Three patients had colorectal cancer. 22490521 2013