|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
|
28118945 |
2017 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.
|
28212920 |
2017 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-DNA, anti-phospholipid, and anti-Ro/SSA autoantibodies are thought to be pathogenic for glomerulonephritis, recurrent thrombosis and miscarriages, and neonatal lupus, respectively.
|
26206675 |
2016 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most cases of neonatal lupus are associated with positive anti-SSA/SSB antibodies in the mother.
|
19488958 |
2010 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus is linked to the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in the mother, although other factors probably of fetal origin are important.
|
17153854 |
2006 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block.
|
16356190 |
2006 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus is an immune-mediated disease associated with the transplacental passage of maternal autoantibodies, primarily anti-Ro (SS-A) and anti-La (SS-B).
|
12542254 |
2002 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is an inflammatory syndrome in the fetus or neonate associated with the presence of anti-Ro(SSA) and anti-La(SSB) antibodies in the mother.
|
10743829 |
2000 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both.
|
10879307 |
2000 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SSA/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart block.
|
11069058 |
2000 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mothers of children with neonatal lupus erythematosus (NLE) and heart block, as well as patients with Sjögren's syndrome (SS) and systemic lupus erythematosus, have serum autoantibodies that recognize SS-A/Ro autoantigens including the 60-kDa ribonucleoprotein.
|
10545525 |
1999 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our findings suggest that there may be immunogenetic differences among mothers according to their autoantibody profiles, and that mothers with both anti-Ro/SSA and anti-La/SSB are more likely to have infants with NLE than mothers with anti-Ro/SSA alone.
|
9546818 |
1997 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HLA class II allele associations with anti-Ro(SS-A) autoantibodies that have been noted in other ethnic groups were also found in Japanese anti-Ro(SS-A)-positive mothers whose infants had NLE, suggesting shared susceptibility factors across racial barriers in maternal predisposition to Ro(SS-A) autoimmune response.
|
9039166 |
1997 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus.
|
9125110 |
1997 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conversely, maternal HLA-DQB1*0602 carried on HLA-DR2 haplotypes was associated with CHB but not cutaneous NLE; (ii) HLA-DQA1 alleles with glutamine at position 34 of the first domain, which have reportedly been associated with the autoimmune responses to Ro/SSA antigens in other ethnic groups, were increased in the mothers of infants with cutaneous involvement; and (iii) there was no particular class II HLA profile that distinguished the disease manifestations in infants.
|
9182815 |
1997 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 52-kD SS-A/Ro protein is one of the antigenic targets strongly associated with the autoimmune response in mothers whose children have manifestations of neonatal lupus.
|
7561701 |
1995 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In approximately 95% of patients, anti-Ro antibody (Ro[SS-A]) has been identified and has become the serologic marker for NLE.
|
7722044 |
1995 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro/SS-A autoantibodies are frequently associated with subacute cutaneous lupus erythematosus, neonatal lupus erythematosus and Sjögren's syndrome.
|
8509157 |
1993 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Examination of paternal and maternal C4 genes of additional infants with NLE, in particular those with CCHB, and of normal infants born to anti-Ro(SS-A)-positive mothers--and of the normal infants' parents--is required to determine if abnormal C4B genes are a critical factor rendering susceptibility to the NLE syndrome.
|
1545698 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, a mother with positive anti-SSA and SSB antibodies can give birth to one infant with and one infant without or have two infants with neonatal lupus erythematosus.
|
1607484 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The spectrum of cutaneous disease in U1RNP antibody-positive infants is similar to Ro (SS-A) antibody-positive infants with NLE.
|
1444503 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was designed to test the hypothesis that anti-Ro(SS-A)/La(SS-B) positive Sjogren's/lupus overlap patients and mothers of infants with neonatal lupus erythematosus syndrome are immunogenetically homogenous and closely related.
|
2584740 |
1989 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since these antibodies may have a pathogenetic role in NLE, screening of infants with isolated CHB and/or cutaneous lesions suggestive of LE, and their mothers, for the presence of Ro(SSA) and La(SSB) antibodies is strongly recommended.
|
6390081 |
1984 |