|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SSA(Ro) antibodies were detected in 48% while seronegative patients were diagnosed with Sjögren's syndrome based on sialadenitis on minor salivary gland biopsy with a focus score ≥1.
|
31354737 |
2019 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren's syndrome: data from a nationwide cohort for Sjögren's syndrome in Korea.
|
31376264 |
2019 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, 87 patients (87%) with anti Ro52+Ro60+ antibodies have autoimmune conditions including Sjögren's syndrome (n=34, 34%), systemic lupus erythematosus (SLE; n=23, 23%), undifferentiated connective tissue diseases (n=12, 12%) and rheumatoid arthritis (n=6, 6%).
|
28663326 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies against Ro52-1 were less frequently found in SSc than in SjS/SLE (11.6 vs. 41.7%, <i>p</i> = 0.001); and antibodies against Ro52-4 were less frequently found in SSc than in SjS/SLE (27.9 vs. 50%, <i>p</i> = 0.03).
|
30581434 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
70 patients with anti-SSA antibody positive SS were selected as the observation group, and the non-positive Sjogren syndrome (PSS) subjects were collected as the control group at the same time.
|
30070316 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro52/SSA, also denoted tripartite motif (TRIM)21, is a major autoantigen in Sjögren's syndrome and systemic lupus erythematosus.
|
30178506 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.
|
29465352 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro60/SSA is a vital auto antigen that is targeted in Sjogren's syndrome and systemic lupus erythematosus (SLE).
|
29274781 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we evaluated immunoreactivity against Ro52-related molecules in SS and healthy volunteers.
|
29463848 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most patients (n = 28, 93%) presented with many annular erythematous patches and plaques with mild pruritus; 22 (73%) had the SS-A antibody and 17 (57%) met the diagnostic criteria of Sjögren syndrome.
|
28771678 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that ACA/SS-A double positive SS is distinct from ACA single positive and SSA single positive SS.
|
29251022 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Post-hoc analysis suggested that there may be subgroups that did respond, such as anti-SSA positive patients with features of Sjogren's syndrome.
|
29542345 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immune Response Targeting Sjögren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice.
|
30261673 |
2018 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Traditional biomarkers for SS include the autoantibodies anti-Sjögren's syndrome-related antigen A (SS-A/Ro), anti-Sjögren's syndrome-related antigen B (SS-B/La), antinuclear antibody (ANA) titers, and rheumatoid factor (RF).
|
28283891 |
2017 |
|
Sjogren's Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS.
|
29242559 |
2017 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This, on the one hand, characterized two autoantigen-targeting microRNAs in Sjögren's syndrome and, on the other hand, suggested that downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjögren's syndrome.
|
26888739 |
2016 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.
|
27460476 |
2016 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lupus-like manifestations consisted of pericarditis, pleuritis, and positive antinuclear and anti-SSA (Sjögren-syndrome A) antibodies.
|
26216333 |
2015 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) of patients with Sjögren's syndrome (SS).
|
25098814 |
2014 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRIM21 is mainly found in hematopoietic cells in which its expression is induced by IFNs during viral. infections and in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome.
|
23975864 |
2013 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52.
|
21862588 |
2011 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A number of systemic features have also been described and the presence of autoantibodies against the ubiquitously expressed ribonucleoprotein particles Ro (Sjögren's-syndrome-related antigen A - SSA) and La (SSB) further underline the systemic nature of Sjögren's syndrome.
|
21777618 |
2011 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy.
|
19330707 |
2009 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro52/Trim21 is targeted as an autoantigen in systemic lupus erythematosus and Sjögren's syndrome.
|
19635858 |
2009 |
|
Sjogren's Syndrome
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome.
|
17552056 |
2007 |