Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, these drugs did not suppress the growth of BRCA2-deficient pancreatic cancer cell lines from humans or gene-targeted mice expressing active Kras and trans-dominant inhibitory mutant Trp53.
|
21289082 |
2011 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PALB2 is a breast and pancreas cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures.
|
21153565 |
2011 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We used nine human cell lines, four with nonmutated BRCA1/2 (MCF7, MDA-MB-231, and HCC1937-BRCA1 [breast cancer] and OSEC-2 [ovarian surface epithelial]), two with mutated BRCA1 (MDA-MB-436 and HCC1937 [breast cancer]), one with mutated BRCA2 (CAPAN-1 [pancreatic cancer]), one that was heterozygous for BRCA2 (OSEC-1 [ovarian surface epithelial]), and one with epigenetically silenced BRCA1 (UACC3199 [breast cancer]), and two Chinese hamster ovary cell lines, parental AA8 and XRCC3 mutated IRS 1SF.
|
21183737 |
2011 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This case highlights the potential benefit for PARP inhibition in BRCA2-related pancreatic cancer.
|
21508395 |
2011 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer.
|
21750719 |
2011 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous small scale studies reported that deleterious BRCA2 and CDKN2a germline mutations contribute to a subset of families with inherited pancreatic cancer.
|
20195775 |
2010 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The screening protocol includes genetic counselling, transcutaneous abdominal ultrasound, magnetic resonance imaging, and blood collection and eligible participants included individuals with a family history of pancreatic cancer or BRCA2 mutation carriers.
|
20623197 |
2010 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Most of the genes listed are responsible for various well-defined cancer syndromes, such as CDKN2A (familial atypical mole-multiple melanoma, FAMMM), the mismatch repair genes (Lynch Syndrome), TP53 (Li-Fraumeni syndrome), APC (familial adenomatous polyposis), and BRCA2 (breast-ovarian familial cancer), where PC is part of the cancer spectrum of the disease.
|
19150414 |
2009 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Inherited risk of pancreatic cancer has been associated with mutations in several genes, including BRCA2, CDKN2A (p16), PRSS1, and PALB2.
|
19690177 |
2009 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additionally, mean ages of diagnosis of pancreatic cancer in BRCA1/2 families differ significantly from the SEER mean (P = 0.0014 for BRCA1 and P = 0.011 for BRCA2 by unpaired t-test).
|
18855126 |
2009 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our case is the first clinical piece of evidence that demonstrates an increased sensitivity to camptothecin-11 and a reduced topoisomerase I relaxation activity in BRCA2 associated pancreatic cancer.
|
19433978 |
2009 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Especially in male BRCA2 mutation carriers under age 65 prostate and pancreatic cancer risks are increased.
|
18657973 |
2008 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations responsible for familial predisposition are mostly unknown, although BRCA2 mutations have been identified in some families and a mutation in the palladin gene has been shown to segregate with pancreatic cancer in one kindred.
|
18818508 |
2008 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Yet, it is not fully elucidated whether the risk for pancreatic cancer attributed to BRCA1 is similar to the high risk conferred by BRCA2.
|
18439109 |
2008 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the true association of BRCA2 mutations with pancreatic cancer may vary among different ethnic groups.
|
18437078 |
2008 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Role of BRCA1 and BRCA2 mutations in pancreatic cancer.
|
16973716 |
2007 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with a high-risk genetic background require counseling, genetic testing if appropriate (BRCA2 mutation or p16INK4A inactivity) and secondary screening for pancreatic cancer in specialist centers.
|
14749618 |
2007 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data suggest that genetic susceptibility to pancreatic cancer may be attributable, in addition to BRCA2, to moderate- to low-penetrance gene(s).
|
17912010 |
2007 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A number of the genes responsible for the aggregation of pancreatic cancer in families have been discovered, including BRCA2, p16/CDKN2A, STK11 and PRSS1.
|
19072437 |
2007 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Five BRCA2 truncating mutations were identified, three in families with two or more first- and second-degree relatives with pancreatic cancer.
|
17301269 |
2007 |
Pancreatic carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The discovery of genetic factors of which the presence predisposes pancreatic cancer to successful targeting, such as the association of BRCA2/Fanconi anemia genes defects and sensitivity to mitomycin C, will eventually lead to a more individualized treatment approach.
|
16648548 |
2006 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Germline BRCA2 mutations predispose to ovarian, breast and pancreatic cancer, while a germline MRE11 mutation is associated with an ataxia telangiectasia-like disorder.
|
16417627 |
2006 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Germline BRCA2 mutations predispose to the development of pancreatic cancer.
|
15806175 |
2005 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, germ line mutations in the BRCA2/FANCD1 Fanconi anemia complementation group gene have also been implicated in predisposition to a number of cancers including pancreatic cancer.
|
15695377 |
2005 |
Pancreatic carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BRCA2, FANCC, and FANCG gene mutations are present in a subset of pancreatic cancer.
|
16243825 |
2005 |