Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Somatostatin (SRIF) and its analogs exhibit antiproliferative effects that are mediated by SRIF receptors (sst) present in responsive normal and neoplastic tissue including breast cancer.
|
8940394 |
1996 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although this is unlikely to have diagnostic or prognostic significance, SSTR2-specific somatostatin analogues may have therapeutic potential in breast cancer.
|
9062398 |
1997 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Somatostatin receptor (sst) subtype 2 mRNA is potently regulated by 17beta-estradiol (E2) in a time and dose-dependent manner in the estrogen receptor (+) human breast cancer cell line T47D.
|
9705075 |
1998 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association analysis of somatostatin receptor (SSTR1 and SSTR2) polymorphisms in breast cancer and solar keratosis.
|
11311492 |
2001 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Relationship between expression of somatostatin receptors subtype 2 mRNA and estrogen and progesterone receptors in breast cancer.
|
14687472 |
2003 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The somatostatin receptor subtype 2 (sst2) is the principal mediator of somatostatin effects in normal and cancer cells, and its presence has already been demonstrated in breast cancer.
|
15163307 |
2004 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Somatostatin receptors in primary human breast cancer: quantitative analysis of mRNA for subtypes 1--5 and correlation with receptor protein expression and tumor pathology.
|
15986128 |
2005 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SST and SSTR2 polymorphisms showed weak but statistically significant associations with breast cancer risk.
|
16214911 |
2005 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study revealed an association of a novel TC repeat polymorphism in the SST promoter with a decreased breast cancer risk in the Polish study population [odds ratio (OR), 0.65; 95% confidence interval (CI), 0.44-0.96].
|
16606630 |
2006 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of somatostatin (SST) and epidermal growth factor (EGF) in breast cancer is undisputed; however, the molecular mechanisms underlying their antiproliferative or proliferative effects are not well understood.
|
19070659 |
2009 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells.
|
21927030 |
2012 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We were interested to evaluate the somatostatin type 2 (SSTR2) and type 4 (SSTR4) receptor expression on a large sample cohort of breast cancer cases.
|
25075022 |
2014 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The modest clinical benefits of SST analogs in cancers of different origin such as breast cancer are attributed to diminished SSTRs expression at tumor sites.
|
26112183 |
2015 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients.
|
27507050 |
2016 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy.
|
28025102 |
2017 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SSTR-Mediated Imaging in Breast Cancer: Is There a Role for Radiolabeled Somatostatin Receptor Antagonists?
|
28450563 |
2017 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Breast carcinomas are known to express somatostatin receptors and this is the first report of Ga-68-DOTA-NOC uptake in a breast tumor.
|
30200073 |
2018 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Somatostatin receptor SSTR2A and SSTR5 expression in neuroendocrine breast cancer.
|
30476894 |
2019 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study revealed that SSTR1 and SSTR4 are the most frequently expressed SSTR subtypes in breast cancer, and that the cell cycle arrest was mediated by SSTR1/SSTR4 dimerization/activation.
|
30675231 |
2019 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of breast cancer cell membranes.
|
31545905 |
2020 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of Somatostatin and Vitamin C on the Fatty Acid Profile of Breast Cancer Cell Membranes.
|
31566138 |
2019 |