Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
New somatostatin-drug conjugates for effective targeting pancreatic cancer.
|
30017114 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer.
|
27608431 |
2016 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We propose that SSTR-2 plays an important role in clinical implications for patients with pancreatic cancer undergoing somatostatin or its analog therapy.
|
25890201 |
2015 |
Malignant neoplasm of pancreas
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that SSTR5 P335L is a hypofunctional protein with a potentially harmful effect on function, as well as potential latent effect, and therefore it could affect the clinical response to somatostatin analog therapy for patients with pancreatic cancer.
|
21249361 |
2011 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
|
19805200 |
2009 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reexpression of human somatostatin receptor gene 2 gene mediated by oncolytic adenovirus increases antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand against pancreatic cancer.
|
19671855 |
2009 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Functional somatostatin receptors (SSTR) are lost in human pancreatic cancer.
|
18823376 |
2008 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesize that reintroduction of SSTR genes back into pancreatic cancer cells might be an effective gene therapy strategy for pancreatic cancer.
|
16183496 |
2005 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models.
|
15706439 |
2005 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we used a powerful real-time RT-PCR technique to examine the mRNA expression levels of all five SSTR subtypes in human pancreatic cancer.
|
15145694 |
2004 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that SSTR2 gene transfer would restore the growth-inhibitory response of human pancreatic cancer to somatostatin.
|
14572771 |
2003 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis.
|
12490654 |
2003 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We created adenoviral constructs containing the SSR2 or Lac-Z gene and transfected somatostatin receptor-negative human pancreatic cancer cells (Panc-1).
|
12069503 |
2002 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transcription of SST2 somatostatin receptor gene in human pancreatic cancer cells is altered by single nucleotide promoter polymorphism.
|
11208729 |
2001 |
Malignant neoplasm of pancreas
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SW-1990 expressed mRNA for SSTR subtypes 3 and 5, whereas various patterns of subtypes 2A, 3, and 5 were found in other pancreatic cancers.
|
11555603 |
2001 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
A subtyping of somatostatin receptors should be carried out before considering a somatostatin analogue treatment in patients with colorectal or pancreatic cancer.
|
8620499 |
1996 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expression of somatostatin receptors should be considered in the design and interpretation of clinical trials with somatostatin analogs for treatment of pancreatic cancer.
|
8751588 |
1996 |
Malignant neoplasm of pancreas
|
0.400 |
Therapeutic
|
disease |
CTD_human |
[Vipoma. 9-year observations using currently available therapy methods].
|
2868874 |
1986 |