|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
SYT/SSX1 translocations are seen in nearly three times as many synovial sarcomas as SYT/SSX2 translocations.
|
15641030 |
2005 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcomas (SS) are characterized by a chromosomal translocation t(X;18)(p11.2;q11.2) which usually fuses the SYT gene from chromosome 18 to SSX1 or SSX2 genes on chromosome X.
|
10879732 |
2000 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The t(X;18)(p11.2;q11.2), which results in fusion of the SYT gene at 18q11 with the SSX1, SSX2, or (rarely) SSX4 gene is a primary genetic event in 90% of SS.
|
17175375 |
2007 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ultimately, an immunohistochemical stain for TLE-1 demonstrated diffusely strong nuclear positivity and molecular studies showed the presence of the t(X; 18) SYT/SSX1 translocation confirming the diagnosis of SS.
|
24436244 |
2014 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX (SSX1 or SSX2) transcriptional repressor.
|
29502955 |
2018 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As a result of the synovial sarcoma associated t(X;18) translocation, the human SYT gene on chromosome 18 is fused to either the SSX1 or the SSX2 gene on the X chromosome.
|
11423977 |
2001 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To address the relationship between the different cellular components found in synovial sarcoma, we deduced the presence of the synovial sarcoma-specific der(X)t(X;18)(p11.2;q11.2), and involvement of the SSX1 gene in both the epithelial/glandular and spindle cell components of 3 biphasic synovial sarcomas with wide ranging proportions of each of the 2 elements.
|
10404078 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification of the t(X;18)(p11.2;q11.2) translocation and detection of the resulting SYT-SSX1 or SYT-SSX2 fusion transcripts are useful diagnostic markers for synovial sarcoma.
|
9688183 |
1998 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma (SS) is characterized by a tumour specific chromosomal translocation t(X;18) (p11;q11) which results in the formation of SYT-SSX1 fusion protein.
|
30219714 |
2018 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is characterized cytogenetically by an X;18 translocation [t (X;18) (p11;q11)] that results in the fusion of the SYT gene from chromosome 18 to either of two highly homologous genes at Xp11, SSX1 or SSX2.
|
9990487 |
1998 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Dual colour fluorescence in situ hybridization to paraffin-embedded samples to deduce the presence of the der(X)t(X;18)(p11.2;q11.2) and involvement of either the SSX1 or SSX2 gene: a diagnostic and prognostic aid for synovial sarcoma.
|
10398111 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, our findings demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects.
|
16152617 |
2006 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin.
|
17197895 |
2007 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Disruption of SSX1 or SSX2, by chromosome translocation and 'in-frame' fusion to SYT, is a consistent feature of synovial sarcomas.
|
9788446 |
1998 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome.
|
10397263 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX 1, 2, or 4.
|
29220290 |
2018 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2.
|
15069540 |
2004 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.
|
11107054 |
2000 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The t(X;18)(p11.2;q11.2) (SYT/SSX1 or SSX2) is represented in more than 95% of synovial sarcoma.
|
10565298 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to analyze the expression of MAGE by immunohistochemistry with mAb 57B in 25 synovial sarcomas (12 monophasic, 13 biphasic), which were typed for the t(X;18)-derived fusion transcript by reverse transcriptase polymerase chain reaction (19 SYT-SSX1, 6 SYT-SSX2).
|
11957149 |
2002 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With this method, 27 tumors (9 synovial sarcomas and 18 nonsynovial sarcomas) were studied and showed SYT-SSX1 rearrangement in 6 cases and SYT-SSX2 in 3 cases.
|
15747098 |
2005 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The three fusion genes that have been detected thus far, SS18/SSX1, SS18/SSX2, and SS18/SSX4, account for more than 95% of the synovial sarcomas.
|
12696068 |
2003 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Fourteen patients with SYT-SSX1 rearrangements and nine patients with biphasic tumor subtypes had better prognosis than the eight patients with SYT-SSX2 rearrangements and 13 patients with monophasic subtypes, respectively.
|
16557383 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Synovial sarcoma (SS) is characterized by a tumour specific chromosomal translocation t(X;18) (p11;q11) which results in the formation of SYT-SSX1 fusion protein.
|
30219714 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SYT-SSX1 transcripts were found in 18/24 (75%) of the tumors while SYT-SSX2 transcripts were identified in 3/24 (12.5%).
|
12469233 |
2003 |