|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
LHGDN |
Biphasic synovial sarcoma expressed the SYT-SSX1 fusion transcript, whereas the monophasic subtype expressed the SYT-SSX2 fusion transcript.
|
15735574 |
2005 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The detection of SYT-SSX1/2 fusion transcripts by RT-PCR is a valuable diagnostic marker of synovial sarcoma which can be used for the reclassification of cases whose diagnosis is difficult by routine methods.
|
15735574 |
2005 |
|
synovial sarcoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This is in contrast to the association between the SYT-SSX1 fusion protein expression and poorer prognosis in soft tissue synovial sarcomas.
|
15879502 |
2005 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With this method, 27 tumors (9 synovial sarcomas and 18 nonsynovial sarcomas) were studied and showed SYT-SSX1 rearrangement in 6 cases and SYT-SSX2 in 3 cases.
|
15747098 |
2005 |
|
synovial sarcoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have shown that SYT-SSX1 is the most common SYT-SSX fusion transcript in biphasic synovial sarcomas of the limbs.
|
15140553 |
2004 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A poorly differentiated synovial sarcoma (SYT/SSX1) expresses neuroectodermal markers: a xenografts and in vitro culture study.
|
15163010 |
2004 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Are there geographical differences in the frequency of SYT-SSX1 and SYT-SSX2 chimeric transcripts in synovial sarcoma?
|
15350633 |
2004 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcomas (SS) consistently show a characteristic chromosomal translocation, t(X;18)(p11;q11), which usually leads to the formation of 2 chimeric fusion transcripts, SYT-SSX1 and -SSX2.
|
15069540 |
2004 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.
|
12696068 |
2003 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study was designed to evaluate the utility of a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect and distinguish SYT-SSX1 and SYT-SSX2 fusions in fresh and archival specimens of synovial sarcoma in pediatric patients seen at St. Jude Children's Research Hospital.
|
12469233 |
2003 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Two homologues of the SSX gene (ie, SSX1 and SSX2) are involved in the vast majority of SS and the SYT-SSX1 type of fusion has been associated with inferior clinical outcome.
|
12707378 |
2003 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The three fusion genes that have been detected thus far, SS18/SSX1, SS18/SSX2, and SS18/SSX4, account for more than 95% of the synovial sarcomas.
|
12696068 |
2003 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
LHGDN |
It has been anticipated that the individual synovial sarcoma carries only one of these variants, however, in this study we demonstrated that SYT-SSX1 and SYT-SSX2 co-exist in a significant proportion of the cases.
|
12037676 |
2002 |
|
synovial sarcoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present investigation, we describe a new SS case that was previously shown to be negative for SYT/SSX1 and SYT/SSX2 expression by conventional reverse transcription polymerase chain reaction (RT-PCR) methods.
|
12065783 |
2002 |
|
synovial sarcoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery.
|
12173050 |
2002 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.
|
12037676 |
2002 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to analyze the expression of MAGE by immunohistochemistry with mAb 57B in 25 synovial sarcomas (12 monophasic, 13 biphasic), which were typed for the t(X;18)-derived fusion transcript by reverse transcriptase polymerase chain reaction (19 SYT-SSX1, 6 SYT-SSX2).
|
11957149 |
2002 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As a result of the synovial sarcoma associated t(X;18) translocation, the human SYT gene on chromosome 18 is fused to either the SSX1 or the SSX2 gene on the X chromosome.
|
11423977 |
2001 |
|
synovial sarcoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, association of SYT-SSX1 with the chromatin remodeling factor hBRM/hSNF2 alpha, which regulates transcription, was demonstrated in both SYT-SSX1-expressing 3Y1 cells and in the human synovial sarcoma cell line HS-SY-II.
|
11274403 |
2001 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcomas (SS) are characterized by a chromosomal translocation t(X;18)(p11.2;q11.2) which usually fuses the SYT gene from chromosome 18 to SSX1 or SSX2 genes on chromosome X.
|
10879732 |
2000 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.
|
11107054 |
2000 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To address the relationship between the different cellular components found in synovial sarcoma, we deduced the presence of the synovial sarcoma-specific der(X)t(X;18)(p11.2;q11.2), and involvement of the SSX1 gene in both the epithelial/glandular and spindle cell components of 3 biphasic synovial sarcomas with wide ranging proportions of each of the 2 elements.
|
10404078 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Dual colour fluorescence in situ hybridization to paraffin-embedded samples to deduce the presence of the der(X)t(X;18)(p11.2;q11.2) and involvement of either the SSX1 or SSX2 gene: a diagnostic and prognostic aid for synovial sarcoma.
|
10398111 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome.
|
10397263 |
1999 |
|
synovial sarcoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The t(X;18)(p11.2;q11.2) (SYT/SSX1 or SSX2) is represented in more than 95% of synovial sarcoma.
|
10565298 |
1999 |