|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer.
|
30936295 |
2019 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer.
|
31081058 |
2019 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results indicate that individual STATs, except STAT1 and STAT2, may act as a favorable prognostic biomarker in breast cancer.
|
29326301 |
2018 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Targeting of STAT1 is a potential treatment strategy for endocrine-resistant breast cancers.
|
30334368 |
2018 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate that stromal STAT1 expression promotes tumor progression and is a potential therapeutic target for breast cancer.<b>Implications:</b> Tumors induce stromal STAT1-dependent cytokine secretion that promotes tumor cell proliferation and can be targeted using clinically-approved inhibitors of STAT1.<i></i>.
|
28108623 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results illustrate that down-regulation of miR-29b in CAFs plays an important role in tumor stroma by activating p38-STAT1 in breast cancer cells.
|
28465475 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
129:Stat1 <sup>-/-</sup> is a unique model for studying the critical origins and risk reduction strategies in age-related ER<sup>+</sup> breast cancer.
|
28865492 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.
|
27862996 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine the role of STAT1 in breast cancer metastasis, we analyzed growth and metastasis in WT or STAT1<sup>-/-</sup> mice orthotopically implanted with metastatic 4T1.2 cells.
|
29147627 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.
|
28276425 |
2017 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activation of the IFN/STAT1 pathway is closely associated with drug response and recurrence of breast cancer treated by chemotherapy.
|
27791205 |
2016 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
ESR1, CCDN1, prolactin, TGFα, AIB1, ESPL1, and WNT1 overexpression, PIK3CA gain of function, as well as loss of P53 (Trp53) or STAT1 are associated with ER+ mammary cancer.
|
24481326 |
2014 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of STAT1 and STAT3 transcript were analysed in 550 breast cancers from publicly available gene expression datasets (GSE2990, GSE12093, GSE6532).
|
24728078 |
2014 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RNAi silencing of Sp1 and STAT1 in breast cancer cells reduced PKCϵ mRNA and protein expression, as well as PRKCE promoter activity.
|
24825907 |
2014 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes belonging to the interferon-related signature for a poor response to therapy.
|
24725474 |
2014 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This analysis revealed a unique set of genes, including Receptor Transporter Protein 4 (RTP4) and STAT1, for which the expression levels can be used to independently predict breast cancer outcome in HER2(+) patients.
|
23592719 |
2013 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that STAT1 activity in breast cancer cells is responsible for shaping an immunosuppressive tumor microenvironment, and inhibiting STAT1 activity is a promising immune therapeutic approach.
|
23486482 |
2013 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
MGD |
Interestingly, the expression levels of STAT1 in the tumor-infiltrating stromal cells remain elevated, indicating that single-cell resolution analysis of STAT1 level in primary breast cancer biopsies is necessary for accurate assessment.
|
22264274 |
2012 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the expression levels of STAT1 in the tumor-infiltrating stromal cells remain elevated, indicating that single-cell resolution analysis of STAT1 level in primary breast cancer biopsies is necessary for accurate assessment.
|
22264274 |
2012 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Differential methylation hybridization profiling identifies involvement of STAT1-mediated pathways in breast cancer.
|
21674123 |
2011 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This is the first study to relate estrogen exposure to increased STAT1 expression in breast cancer cells, an effect that may represent an additional role of estrogen in the pathogenesis of breast cancer.
|
21185374 |
2011 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
|
19915608 |
2010 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
MGD |
Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta.
|
18209032 |
2008 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
MGD |
Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.
|
18493980 |
2008 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
MGD |
The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN.
|
17475277 |
2007 |