Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.330 Biomarker disease BEFREE RPV ameliorates liver fibrosis through selective STAT1-dependent induction of apoptosis in HSC, which exert paracrinal effects in hepatocytes, thus promoting liver regeneration. 31530714 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.330 AlteredExpression disease BEFREE Consistent with the results of in vitro study, intrahepatic IFN-γ/STAT1 levels increased in relation to the severity of liver fibrosis in BA patients, and the altered balance between MMP2 and TIMP1 expressions in livers may contribute to increased deposition of extracellular matrix and fibrosis. 28304404 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.330 Biomarker disease BEFREE Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery. 28322315 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.330 Therapeutic disease CTD_human In conclusion, activation of STAT1 attenuates liver fibrosis through inhibition of HSC proliferation, attenuation of TGF-beta signaling, and stimulation of NK cell killing of activated HSCs. 17133483 2006