Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
|
12957465 |
2003 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.
|
19137011 |
2009 |
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
One potential mechanism by which HBx can cause liver cancer may involve intracellular distribution and consecutively modulation of the proliferative important STAT/SOCS signaling with upregulation of STAT3.
|
19321929 |
2008 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite these versatile and occasionally antagonistic interactions, NF-kappaB and STAT3 cooperate to promote the development and progression of colon, gastric and liver cancers.
|
20018552 |
2010 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The negative crosstalk between NF-kappaB and STAT3, which is also evident in human HCC, is a critical regulator of liver cancer development and progression.
|
20227042 |
2010 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.
|
24912675 |
2014 |
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer.
|
25063062 |
2014 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
We proposed that PKM2 activates transcription of hypoxia inducible factor-1α (HIF-1α) by phosphorylating STAT3 (signal transducer and activator of transcription 3) at Y705 (tyrosine 705) as a plausible mechanism for liver cancer cell proliferation.
|
25661370 |
2015 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo.
|
28187727 |
2017 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, to explore whether 8-bromo-7-methoxychrysin (BrMC) inhibits liver cancer stem-like cell (LCSLC) properties via disrupting STAT3/Twist signaling, we cultured SMMC-7721 cells in vitro, and evaluated the effects of BrMC on the stemness of spheroids by determining the sphere-forming capability and migration.
|
28369327 |
2017 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, few inhibitors targeting up-streams of STAT3 are available for the therapy of liver cancer.
|
28430601 |
2017 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is no STAT3 inhibitors approved to be used clinically for the treatment or prevention of liver cancer.
|
28714512 |
2017 |
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4.
|
28810927 |
2017 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
|
29151958 |
2017 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since STAT3 plays a key role in invasion, migration, and metastasis of cancer, we investigated whether ent-sauchinone could exert promising inhibitory effects on the invasion and migration of the metastatic human liver cancer cell line SMMC-7721 in the present study. ent-Sauchinone was extracted from dried herbs of Saururus chinensis (Lour.)Baill.
|
29495104 |
2018 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Though embryonic liver fodrin (ELF) is a pro-differentiation protein, it was expressed in the CD13 positive liver cancer stem cells along with stem cell markers such as Oct-4 and STAT3.
|
29630108 |
2018 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, the STAT3-S1PR pathway that has been reported previously to mediate the effect of SphK1 on colorectal cancers was not altered by SphK1 deletion in liver cancer.
|
29643998 |
2018 |
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Notably, STAT3 transcription activity, indicated by its phosphorylation on Y705 is heterogeneous in different liver cancer cell lines.
|
29805309 |
2018 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The permanent activation of hepatocellular carcinoma-associated proto-oncogenes such as c-Jun and associated transcription factors including STAT3 by substances released from tissue-trapped schistosome eggs may be important factors contributing to the development of liver cancer in S. mansoni-infected patients.
|
30053321 |
2018 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results of the present study highlight the pivotal function of microRNA-543 as an inhibitor in liver cancer cell proliferation by observing JAK2/STAT3/c-Myc/Bcl-2 in liver cancer.
|
30675310 |
2019 |
Malignant neoplasm of liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical results revealed that STAT3 activation was positively correlated with increased HSD17B4 expression in tumor tissues from patients with liver cancer.
|
30747222 |
2019 |
Malignant neoplasm of liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study suggested that HOAX11-AS could regulate the JAK-STAT signaling pathway by miR-15a-3p/STAT3 axis to promote the progression of liver cancer.
|
31099097 |
2019 |
Malignant neoplasm of liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity.
|
31560893 |
2019 |