Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The relationship of this aberrancy of ovarian carcinoma harboring activated Stat 3 deserves further investigation.
|
11006034 |
2000 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas.
|
12061840 |
2002 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
STAT3 is frequently phosphorylated and activated in breast and ovarian cancers, where cytokines and growth factors up-regulate STAT3 and stimulate proliferation.
|
16061651 |
2005 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Stat3 expression in ovarian cancer tissue microarray was evaluated by immunohistochemistry.
|
16951221 |
2006 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
The activation and translocation of pStat3 to the nucleus are frequent events in ovarian carcinoma that are associated with a poor prognosis.
|
17063503 |
2006 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Constitutively activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the formation of many tumors including ovarian cancer.
|
18535750 |
2008 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the IL-6-Stat3 pathway contributes to tumor cell growth, survival and drug resistance in several cancers, including ovarian cancer.
|
18587580 |
2009 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hyperactive EGFR signaling through Stat3 and the Jak-Stat3 activity together promote ovarian cancer progression to cisplatin resistance and therefore represent targets for preventing the development of cisplatin resistance and the recurrent disease during cisplatin therapy in ovarian cancer.
|
21909139 |
2012 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Signal transducer and activator of transcription 3 (STAT3) is activated in majority of ovarian tumors and confers resistance to cisplatin treatment in patients with ovarian cancer.
|
22280969 |
2012 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to investigate whether the STAT3 inhibitor HO-3867, a novel curcumin analog, has a therapeutic effect on BRCA1-mutated ovarian cancer.
|
22801507 |
2012 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin (IL)-6 and Stat3 play key roles in ovarian cancer progression.
|
23536726 |
2013 |
Malignant neoplasm of ovary
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer.
|
23604529 |
2013 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results revealed that the STAT3 decoy ODN inhibited ovarian cancer cell growth and promoted ovarian cancer cell apoptosis in vivo.
|
23828376 |
2013 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, these findings emphasize the importance of Stat3 in cisplatin resistance in ovarian cancer and provide a further impetus to clinically evaluate biological modifiers that may circumvent cisplatin resistance in patients with chemoresistant ovarian cancer.
|
23962558 |
2013 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results offer preclinical proof-of-concept for HO-3867 as a selective STAT3 inhibitor to treat ovarian cancer and other solid tumors where STAT3 is widely upregulated.
|
24590057 |
2014 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that a combined approach of targeting high-invasive OVCA cells by blocking glutamine's entry into the TCA cycle, along with targeting low-invasive OVCA cells by inhibiting glutamine synthesis and STAT3 may lead to potential therapeutic approaches for treating OVCAs.
|
24799285 |
2014 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
JAK/STAT3 is one of the major signaling pathways that is aberrantly activated in ovarian cancer and associated with tumor progression and poor prognosis in patients with ovarian cancer.
|
25319391 |
2014 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Results of the present study suggested that combined therapy with eukaryotic co-expression of the plasmid‑carrying STAT3-specific siRNA and LKB1 is a novel and efficient treatment strategy for human ovarian cancer.
|
25420630 |
2015 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian cancer via regulation of the STAT3 and PI3K/Akt signaling pathways.
|
26983899 |
2016 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, anti-miR551b reduced STAT3 expression in ovarian cancer cells in vitro and in vivo and reduced ovarian cancer growth in vivo.
|
27160903 |
2016 |
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target.
|
27292260 |
2017 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
We further demonstrated that a STAT3/JAK2 inhibitor could potently sensitize platinum-resistant cells to carboplatin and suppress their growth in vivo Our findings offer a mechanistic rationale to target the PBX1/STAT3 axis to antagonize a key mechanism of chemoresistance in ovarian cancers and possibly other human cancers.
|
27590741 |
2016 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway.
|
27981892 |
2017 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer.
|
28188387 |
2017 |
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer.
|
28209618 |
2017 |