|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Antigrowth synergy of expression was preserved for antiapoptotic Bak and proliferation-suppressing E-cadherin in IA adenocarcinomas (p = .031, r = 0.342) with no significance between Bak and E-cadherin or STAT3 and emerging correlation between E-cadherin and Bcl-xL in IB + II tumors instead (p = .003, r = 0.472).
|
28937296 |
2018 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Finally, animals with subcutaneous R3230 adenocarcinoma tumors were allocated to RFA or sham treatment with or without a STAT3 inhibitor (S3I-201 or micellar curcumin, eight arms).
|
28880787 |
2018 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Malignant growths in the gp130(F/F):Kras(G12D) model displayed features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma throughout the lung, as compared with parental Kras(G12D) mice, where STAT3 was not hyperactivated.
|
26744530 |
2016 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts.
|
26432044 |
2015 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
STAT3 nuclear translocation was more frequent in adenocarcinomas and squamous cell carcinomas than that of their noncancerous counterparts.
|
26432044 |
2015 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas.
|
23912451 |
2014 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Over-activation of the signal transducers and activators of the transcription 3 (Stat3) pathway in lung alveolar type II (AT II) epithelial cells induces chronic inflammation and adenocarcinoma in the lung of CCSP-rtTA/(tetO)7-CMV-Stat3C bitransgenic mice.
|
23613996 |
2013 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This review will discuss the mechanics of STAT3 signalling, how constitutive STAT3 activation promotes gastric tumourigenesis in both human adenocarcinomas and mouse models, the nature of the upstream regulators of STAT3, and their association with chronic Helicobacter pylori infection, STAT3-activated genes that promote transformation and progression, and finally the development and use of STAT3 and upstream cytokine inhibitors as therapeutics.
|
22834702 |
2012 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with TLR4-D299G than those with wild-type TLR4.
|
21920464 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of p-STAT3 was detected by immunohistochemistry in tissue from 127 lung carcinomas (100 adenocarcinomas and 27 squamous cell carcinomas) and 56 normal lungs.
|
22208386 |
2011 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Further evaluations indicated that phospho-Stat3, phospho-Akt, phospho-nuclear factor κB, cyclin D1, and Ki67 were upregulated in adenocarcinomas from ARR(2)Pb.Stat3C x PTEN(+/-) mice.
|
21390188 |
2011 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These STAT3-mediated regulatory circuits are required for the transformed state in diverse cell lines and tumor growth in xenografts, and their transcriptional signatures are observed in colon adenocarcinomas.
|
20797623 |
2010 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies.
|
19028472 |
2009 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A panel of Stat3-up-regulated downstream genes in mice was up-regulated in human adenocarcinomas, but not in human squamous cell carcinomas.
|
18614255 |
2009 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Significance of p-STAT3 expression in human colorectal adenocarcinoma.
|
18695911 |
2008 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.
|
18060032 |
2007 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
OPN expression was investigated immunohistochemically in 104 adenocarcinomas and 38 MM and correlated with histological features, including tumour type, grade and proliferation and with expression of activated intermediary EGFR signalling pathway molecules p65, p-AKT, p-ERK, p-STAT-3, and of metalloproteinase (MMP)-1, MMP-2 and MMP-9.
|
17493236 |
2007 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis.
|
17203226 |
2007 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
To our knowledge, this is the first study on the poor prognosis of p-STAT3 in human colorectal adenocarcinomas.
|
16685378 |
2006 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the present study, we explored the capacity of progestins to modulate Stat3 transcriptional activation in an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in BALB/c mice and in the human breast cancer cell line T47D.
|
15923602 |
2005 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues.
|
12438264 |
2002 |