Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, the results suggest that <i>STAT3</i> in T cells may be a therapeutic target in ulcerative colitis by balancing the immune response through T cell homeostasis.
|
30181918 |
2018 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Altogether, IL-9 participates in the pathogenesis of UC through STAT3/SOCS3 signaling pathway and has the potential to serve as a possible therapeutic candidate in patients with UC.
|
30369485 |
2018 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Ulcerative colitis (UC) is characterized by aberrant regulation of tight junctions (TJ), signal transducer and activator of transcription 3 (STAT3), and interleukin (IL)-8/18, which lead to intestinal barrier defects.
|
30241336 |
2018 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interleukin‑6 (IL‑6)/signal transducer and activator of transcription 3 (STAT3) pathway plays essential roles in the development of inflammatory diseases including ulcerative colitis (UC).
|
29845215 |
2018 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study provides evidence that miR-495 improves the intestinal mucosal barrier function by targeting STAT3 through inhibiting the JAK/STAT3 signaling pathway in UC mice.
|
29129493 |
2018 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Targeting miR-124 and STAT3 represents a novel approach for treating ulcerative colitis.
|
27709266 |
2017 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This is the first study of the single marker association of IL23R, JAK2, and STAT3 polymorphisms with ulcerative colitis and Crohn's disease in a Turkish population.
|
27852544 |
2016 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated whether high SOCS3 increased risk for relapse through violating STAT3-dependent protective effects of interleukin (IL)-22 during UC remission.
|
25545374 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study implies that the STAT3 rs2293152 polymorphism may be associated with the occurrence of UC and might be used as a predictive factor for UC in the Chinese Han population.
|
24781989 |
2014 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the STAT3 rs744166 polymorphism was associated with CD and UC susceptibility (CD: GA+AA vs. GG, OR = 1.20, 95%CI, 1.11-1.30, I2 = 0%, Punadjusted<0.00001, PBonferroni<0.00005, PFDR<0.00001; UC: GA+AA vs. GG, OR = 1.21, 95%CI, 1.08-1.36, I2 = 1%, Punadjusted = 0.001, PBonferroni = 0.005, PFDR = 0.00125).
|
25286337 |
2014 |
Ulcerative Colitis
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Levels of miR-124 were decreased, whereas levels of STAT3 phosphorylation increased in colon tissues from pediatric patients with active UC compared with those with inactive disease.
|
23856509 |
2013 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
DAPK as a negative regulator of STAT3 emerges as therapeutic option in the treatment of ulcerative colitis and UCC.
|
23438478 |
2013 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC.
|
21631466 |
2012 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.
|
22962574 |
2012 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data on genetic interaction reveals that the above JAK2 and STAT3 risk alleles contribute to CD susceptibility in combination with each other (OR: 2.218; 95% CI: 1.097-4.487; P = 0.024), while the JAK2 variant shows a tendency to confer UC risk only on a wild-type STAT3 background (OR: 1.997, 95%CI: 0.994-4.009, P = 0.049).
|
22269120 |
2012 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.
|
21574661 |
2011 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population.
|
20200543 |
2010 |
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
|
19926618 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the adaptive immune response, IL23R, MST1, IL12B, and STAT3 polymorphisms are associated with Crohn's disease and ulcerative colitis.
|
19647622 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.
|
18800073 |
2009 |