Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Collectively, the results suggest that <i>STAT3</i> in T cells may be a therapeutic target in ulcerative colitis by balancing the immune response through T cell homeostasis. 30181918 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Altogether, IL-9 participates in the pathogenesis of UC through STAT3/SOCS3 signaling pathway and has the potential to serve as a possible therapeutic candidate in patients with UC. 30369485 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Ulcerative colitis (UC) is characterized by aberrant regulation of tight junctions (TJ), signal transducer and activator of transcription 3 (STAT3), and interleukin (IL)-8/18, which lead to intestinal barrier defects. 30241336 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Interleukin‑6 (IL‑6)/signal transducer and activator of transcription 3 (STAT3) pathway plays essential roles in the development of inflammatory diseases including ulcerative colitis (UC). 29845215 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Our study provides evidence that miR-495 improves the intestinal mucosal barrier function by targeting STAT3 through inhibiting the JAK/STAT3 signaling pathway in UC mice. 29129493 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Targeting miR-124 and STAT3 represents a novel approach for treating ulcerative colitis. 27709266 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE This is the first study of the single marker association of IL23R, JAK2, and STAT3 polymorphisms with ulcerative colitis and Crohn's disease in a Turkish population. 27852544 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE We investigated whether high SOCS3 increased risk for relapse through violating STAT3-dependent protective effects of interleukin (IL)-22 during UC remission. 25545374 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE Our study implies that the STAT3 rs2293152 polymorphism may be associated with the occurrence of UC and might be used as a predictive factor for UC in the Chinese Han population. 24781989 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE The results indicated that the STAT3 rs744166 polymorphism was associated with CD and UC susceptibility (CD: GA+AA vs. GG, OR = 1.20, 95%CI, 1.11-1.30, I2 = 0%, Punadjusted<0.00001, PBonferroni<0.00005, PFDR<0.00001; UC: GA+AA vs. GG, OR = 1.21, 95%CI, 1.08-1.36, I2 = 1%, Punadjusted = 0.001, PBonferroni = 0.005, PFDR = 0.00125). 25286337 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 PosttranslationalModification disease BEFREE Levels of miR-124 were decreased, whereas levels of STAT3 phosphorylation increased in colon tissues from pediatric patients with active UC compared with those with inactive disease. 23856509 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE DAPK as a negative regulator of STAT3 emerges as therapeutic option in the treatment of ulcerative colitis and UCC. 23438478 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC. 21631466 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. 22962574 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC. 22065112 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE Data on genetic interaction reveals that the above JAK2 and STAT3 risk alleles contribute to CD susceptibility in combination with each other (OR: 2.218; 95% CI: 1.097-4.487; P = 0.024), while the JAK2 variant shows a tendency to confer UC risk only on a wild-type STAT3 background (OR: 1.997, 95%CI: 0.994-4.009, P = 0.049). 22269120 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease BEFREE Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. 21574661 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 Biomarker disease CTD_human Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 20228799 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population. 20200543 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 AlteredExpression disease BEFREE Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. 19926618 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE In the adaptive immune response, IL23R, MST1, IL12B, and STAT3 polymorphisms are associated with Crohn's disease and ulcerative colitis. 19647622 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.500 GeneticVariation disease BEFREE In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility. 18800073 2009