Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results highlight the TRIM27 expression significantly increased by IL-6 and suggest a TRIM27/STAT3-dependent mechanism for regulation of inflammation and proliferation-associated development of psoriasis.
|
31747314 |
2020 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
|
31495284 |
2019 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study suggests that Stat3 activation in keratinocytes may impact on LC activation in situ via IL-1α stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23.
|
30514663 |
2019 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Further, AS2762900-00 showed an inhibitory effect on signal transducer and activator of transcription 3 (STAT3) phosphorylation as a downstream signal of IL-23 receptor activation in whole blood from patients with psoriasis.
|
30472202 |
2019 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes.
|
30743203 |
2019 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Several common TFs that bind the promoters of the DEGs, including the well-known signal transducer and activator of transcription 1 (STAT1), STAT3, and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) as well as ETS homologous factor (EHF), Fos-like antigen 1 (FOSL1), and Forkhead box C1 (FOXC1), which are rarely studied in psoriasis, were also identified.
|
30825251 |
2019 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Silencing the target gene STAT3 in psoriatic KCs with siRNA combined with ultrasonic irradiation and microbubbles would contribute to a significant innovation as a new clinical therapy for psoriasis.
|
30127220 |
2018 |
Psoriasis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Psoriasis: A STAT3-Centric View.
|
29316631 |
2018 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
It was observed that 'psoriasis 1' downregulated the concentrations of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and upregulated the concentration of 25HVD3; furthermore, 'psoriasis 1' downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level of VDR in TNF‑α‑induced HaCaT cells.
|
30015892 |
2018 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicated that the curative effects of CTS on psoriasis are accomplished mainly through modulating STAT3, which providing evidences to develop CTS as a potential therapeutic agent for patients with psoriasis.
|
29427477 |
2018 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
STAT3 was overexpressed in the intestinal mucosa of active and non-active IBD, and a similar upregulation was seen in skin biopsies from EN [84.7 vs 22.3, p < 0.001] and PG [60.5 vs 22.3, p = 0.011], but not in psoriasis.
|
29182760 |
2018 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IL-22-STAT3-Bcl-3 pathway may be important in the pathogenesis of psoriasis.
|
28901004 |
2018 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation.
|
29949348 |
2018 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that miR-320b negatively regulates NHEK proliferation by targeting AKT3 to regulate the STAT3 and SAPK/JNK signaling pathways and might participate in the pathogenesis of psoriasis in Chinese Han populations. miR-320b may also be a novel diagnostic marker or therapeutic target for this disease.
|
30136020 |
2018 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Together, our results reveal a novel regulatory mechanism of IL-22 expression by STAT1 through directly antagonizing STAT3, and the importance of the balance between STAT3 and STAT1 in IL-22 regulation and psoriasis pathogenesis.
|
29750958 |
2018 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Herein, we reported that K17 could be modified through ubiquitination that controlled its stability and led to the phosphorylation and nuclear translocation of its interactor signal transducers and activators of transcription 3 (STAT3), which is a key regulator of cell proliferation in psoriasis.
|
29859926 |
2018 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The level of STAT3 mRNA and pSTAT3 was higher, but let-7a expression was lower in the psoriasis group than the control group.
|
28494466 |
2017 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Several mouse models of psoriasis including drug-induced models (topical application of imiquimod to the skin) and genetically engineered mice (constitutive activation of epidermal STAT3, epidermal deletion of JunB/c-Jun, and epidermal overexpression of Tie2) have been used to study the pathophysiology of the disease; however such models cannot fully recapitulate all molecular and cellular pathways occurring in human psoriasis.
|
28063039 |
2017 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We also found that IL-22 increases CD147 transcription in vitro and in vivo and that Stat3 binds directly to the CD147 promoter between positions -854 and -440, suggesting that CD147 expression is up-regulated in patients with psoriasis through Stat3 activation.
|
28272440 |
2017 |
Psoriasis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis (p < 0.05).
|
28420002 |
2017 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data suggest that systemic IL-23/STAT3 axis is responsible for enhanced airway inflammation during psoriasis.
|
27984001 |
2017 |
Psoriasis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Collectively, our study indicated that CAV-1 participates in the pathogenesis of psoriasis by regulating the STAT3 pathway and cytokine networks.
|
26134945 |
2015 |
Psoriasis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We further show that overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells.
|
24610393 |
2014 |
Psoriasis
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has been demonstrated that epidermal Stat3 activation is required for psoriasis development, since keratinocyte-specific Stat3 activation in a mouse model elicits a psoriasis-like phenotype, which is reversed by inhibition of Stat3 signaling.
|
23870655 |
2013 |