Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We further found that tumour-intrinsic STAT3 regulates the durability of the antiproliferative activity of FAK inhibitor, and combinatorial targeting of FAK and Janus kinase/STAT3 act synergistically to suppress pancreatic cancer progression in mouse models.
|
31076405 |
2020 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Co-culture with macrophages increased pancreatic cancer cell migration and activated STAT3.
|
28476581 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Signal transducer and activator of transcription (STAT3) is a constitutively expressed protein in human pancreatic cancers and is associated with their poor prognosis.
|
31089934 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the YY1/FER/STAT3/MMP2 axis is associated with the progression of pancreatic cancer and may provide a new therapeutic target for the treatment of pancreatic cancer.
|
31404611 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
In general, this study indicated that SAM synergistically enhanced the antitumor effect of GEM against PC through suppressed JAK2/STAT3 pathway, and SAM is applicable as a promising agent to improve the sensitivity of PC to GEM.
|
30683944 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-IL-9 antibody could effectively restrain the growth of pancreatic cancer in mice, and this effect may partly occur by blocking the STAT3 pathway.
|
31647203 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correction: Retraction: A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells.
|
31039211 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the current study, using a humanized mouse model, we aimed to develop a combination therapy with an anti-PD-1 antibody and a STAT3 inhibitor (STX-0119) for use in vivo against pancreatic cancer.
|
31586551 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that targeting prolactin together with IL6, a known major activator of STAT3, could represent a novel therapeutic strategy for treating pancreatic cancer.
|
31395607 |
2019 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To examine mechanisms that underlie STAT3 function in cancer, we evaluated the impact of STAT3 activity in KRAS-driven lung and pancreatic cancer.
|
30135074 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727.
|
30065235 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.
|
30154150 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we explored the potential utility of FTY720 to target S1PR1/STAT3 and other major signaling pathways in pancreatic cancer, and sought proof-of-principle for repurposing FTY720 for the treatment of pancreatic cancer.
|
30083262 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways.
|
29858050 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the STAT3 represents a potential drug target for pancreatic cancer therapy.
|
29606890 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer.
|
29572224 |
2018 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We reveal a novel mechanism by which BRM could activate JAK2/STAT3 pathway to promote pancreatic cancer growth and chemoresistance.
|
28602977 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, the ability of both STAT3 inhibitors to inhibit colony formation in pancreatic cancer, medulloblastoma and sarcoma cell lines was reduced under hypoxic conditions when compared to cells under normoxic conditions.
|
28179300 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.
|
28795470 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that "Nx-mediated inhibition of survival molecules like STAT3 and NF-κB in pancreatic cancer cells will improve the efficacy of the conventional chemotherapeutic agent, gemcitabine (GEM)."
|
27208550 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together our findings suggest that miR-1181 may be involved in pancreatic cancer cell invasion and proliferation by targeting STAT3 and indicate that miR-1181 may be a potential therapeutic agent for pancreatic cancer.
|
28321160 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Notably, the bromodomain inhibitors also reduced protein levels of p-Erk 1/2 and p-STAT3 in mouse models of pancreatic cancer.
|
28254412 |
2017 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.
|
27875298 |
2016 |
Malignant neoplasm of pancreas
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, HIC1 appears to function as a STAT3 inhibitor and may be a promising target for cancer research and for the development of an optimal treatment approach for pancreatic cancer.
|
27085461 |
2016 |
Malignant neoplasm of pancreas
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PSC-CM induced the activation of STAT3 in pancreatic cancer cells.
|
26738736 |
2016 |