Primary biliary cirrhosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
Immunogenetic studies have identified polymorphisms of the IL-12/STAT4 pathway as being associated with PBC.
|
31803181 |
2019 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
The effect of ICOSLG and CXCR5 variants were concordant but the effect of STAT4, NFKB1 and IL12B variants were discordant for PBC and CD.
|
26084578 |
2015 |
Primary biliary cirrhosis
|
0.470 |
PosttranslationalModification
|
disease |
BEFREE |
This effect was mediated by the rapid and strong phosphorylation of STAT4 on Treg cells from patients with PBC and pSS (p < 0.05) but not PSC and HC.
|
30119881 |
2018 |
Primary biliary cirrhosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
Potential functional implications of key findings are discussed including the IL-12/STAT4 pathway in PBC and the CD28/IL-2 pathway in PSC.
|
26347073 |
2016 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
|
23000144 |
2012 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC).
|
25798064 |
2015 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
|
23000144 |
2012 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
|
22936693 |
2012 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of individuals of European descent, three loci (IL7R, IKZF3, and CD80) showed significant associations (combined p = 3.66 × 10(-8), 3.66 × 10(-9), and 3.04 × 10(-9), respectively) and STAT4 and NFKB1 loci showed suggestive association with PBC (combined p = 1.11 × 10(-6) and 1.42 × 10(-7), respectively) in the Japanese population.
|
23000144 |
2012 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.
|
28425483 |
2017 |
Primary biliary cirrhosis
|
0.470 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
|
21399635 |
2011 |
Primary biliary cirrhosis
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
Primary biliary cirrhosis
|
0.470 |
Biomarker
|
disease |
BEFREE |
Our findings confirm that STAT4 is involved in PBC susceptibility and may play a role in ANA status in the Japanese population.
|
24648611 |
2014 |