|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
<b>Objectives:</b> The signal transducer and activator of transcription 4 (<i>STAT4</i>) gene encodes an important transcription factor that transmits signals induced by several cytokines associated with autoimmune diseases and has been identified as a susceptibility gene for numerous autoimmune disorders.
|
30666271 |
2018 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) gene encode a transcriptional factor that transmits signals induced by several key cytokines which play important roles in the development of autoimmune diseases.
|
21683716 |
2011 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
STAT4 is an important transcription factor that contributes to the incidence and severity of different autoimmune diseases and is implicated in the antiviral immune responses in mice.
|
22718836 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) transmits signals induced by interleukin-12, interleukin-23 and interferon-γ, which are key cytokines and play important roles in the development of autoimmune diseases.
|
23727609 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity.
|
24312163 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
STAT4 has been consistently associated with several autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
|
27178308 |
2016 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
STAT4 plays a crucial role in the functioning of the innate and adaptive immune cells and has been identified as a susceptibility gene in numerous autoimmune disorders.
|
28852993 |
2017 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
A large genetic study in 2566 IIM patients revealed associations such as PTPN22, STAT4, UBE2L3 and BLK, which overlap with risk variants reported in other seropositive autoimmune diseases.
|
27466937 |
2016 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A redundant interaction between IRF5 and STAT4 polymorphisms was found in susceptibility to the type I interferon pathway-associated rheumatic autoimmune diseases, SLE and RA, calling for further studies on confirmation of these findings.
|
24014567 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Among these autoimmunity risk genes are IFN regulatory factor 5 (IRF5), which is involved in TLR signaling, and the signal transducer and activator of transcription 4 (STAT4) that interacts with the type I IFN receptor.
|
22066971 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
As the TT genotype is associated with autoimmune diseases, our results seem at a paradox with current evidence hinting at a different role of STAT4 in normal circumstances versus immunocompromised patients.
|
27960128 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
But, no significant differences in allele and genotype frequencies of STAT4 rs7574865 polymorphism were detected according to the presence of another autoimmune disease, nodules and in HLA-DRB1*04 and HLA-DRB1*0404 positive subgroups.
|
21418779 |
2011 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+ memory T cells from multiple sclerosis patients had significantly higher levels of p-STAT3/p-STAT4, and p-STAT3/p-STAT4 heterodimers were observed upon IL-23 signaling, suggesting that p-STAT3/p-STAT4 induced by IL-23 signaling orchestrate the generation of pathogenic T cells in CNS autoimmunity, regardless of Th1 or Th17 phenotype.
|
28878115 |
2017 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Changes in the expression of signal transducer and activator of transcription 4 (STAT4) contribute to the development of a variety of autoimmune diseases including inflammatory bowel diseases (IBDs).
|
22569826 |
2012 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
|
19109131 |
2009 |
|
Autoimmune Diseases
|
0.200 |
PosttranslationalModification
|
group |
BEFREE |
Different factors, such as genetic factors (CD25, STAT4), epigenetic factors (DNA methylation, histone modifications) and environmental factors (xenobiotics, drugs, hormones) trigger autoimmunity.
|
31059841 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population.
|
22069275 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Further work suggested that the BS associated variant of STAT4 is not related to the previously reported one associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
|
24064024 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE).
|
19796918 |
2010 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
However, in the DSS model, the STAT4 transcription in CECs, which are the target cells of activated T cells in the gut, was downregulated by baicalin, suggesting that baicalein and baicalin mediated similar STAT expression in different cell types in autoimmune diseases.
|
29845272 |
2018 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In concert with the identification of other disease-associated loci, elucidating how the variant form of STAT4 modulates immune function should lead to an improved understanding of the pathophysiology of autoimmunity.
|
18682104 |
2008 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases.
|
23985571 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |