|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.
|
19565500 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are shared susceptibility genes for various autoimmune diseases.
|
23985571 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrates that the STAT4 rs7574865 T allele confers susceptibility to SLE, RA, T1D, SSc, JIA, APS, IBD-UC, and pSS patients, supporting the hypothesis of association between STAT4 gene polymorphism and subgroup of autoimmune diseases.
|
22714917 |
2012 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recent studies have indicated associations of rs7574865 single nucleotide polymorphism (SNP) in the STAT4 gene with various autoimmune diseases.
|
27126090 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 polymorphism on acute allograft rejection.
|
21237270 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This is the first study to show a positive association between a STAT4 polymorphism and type-1 autoimmune hepatitis, suggesting that autoimmune hepatitis shares a gene commonly associated with risk for other autoimmune diseases.
|
23990947 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recently, the signal transducer and activator of transcription 4 (STAT4) gene has been associated with multiple autoimmune diseases.
|
20153791 |
2010 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Among these autoimmunity risk genes are IFN regulatory factor 5 (IRF5), which is involved in TLR signaling, and the signal transducer and activator of transcription 4 (STAT4) that interacts with the type I IFN receptor.
|
22066971 |
2011 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
However, in the DSS model, the STAT4 transcription in CECs, which are the target cells of activated T cells in the gut, was downregulated by baicalin, suggesting that baicalein and baicalin mediated similar STAT expression in different cell types in autoimmune diseases.
|
29845272 |
2018 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) transmits signals induced by interleukin-12, interleukin-23 and interferon-γ, which are key cytokines and play important roles in the development of autoimmune diseases.
|
23727609 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Taken together, these results suggest that STAT4 polymorphisms are associated with autoimmune diseases which are characterized by a systemic pathology and anti-dsDNA antibody.
|
23628400 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We also found evidence for association (P < 1 x 10(-5)) at FCGR2A, PTPN22 and STAT4, regions previously associated with SLE and other autoimmune diseases, as well as at > or =9 other loci (P < 2 x 10(-7)).
|
18204446 |
2008 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Our results indicate that STAT4 is a common genetic risk factor for autoimmune diseases, with similar strength across major racial groups.
|
18576330 |
2008 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
STAT4 plays a crucial role in the functioning of the innate and adaptive immune cells and has been identified as a susceptibility gene in numerous autoimmune disorders.
|
28852993 |
2017 |
|
Autoimmune Diseases
|
0.200 |
PosttranslationalModification
|
group |
BEFREE |
Different factors, such as genetic factors (CD25, STAT4), epigenetic factors (DNA methylation, histone modifications) and environmental factors (xenobiotics, drugs, hormones) trigger autoimmunity.
|
31059841 |
2019 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The signal transducer and activator of transcription 4 (STAT4) gene is one of the most interesting genes for the pathogenesis of autoimmune diseases, including T1D.
|
23360093 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE).
|
19796918 |
2010 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
As the TT genotype is associated with autoimmune diseases, our results seem at a paradox with current evidence hinting at a different role of STAT4 in normal circumstances versus immunocompromised patients.
|
27960128 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes.
|
20454450 |
2010 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) gene encode a transcriptional factor that transmits signals induced by several key cytokines which play important roles in the development of autoimmune diseases.
|
21683716 |
2011 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
STAT4 is an important transcription factor that contributes to the incidence and severity of different autoimmune diseases and is implicated in the antiviral immune responses in mice.
|
22718836 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
<b>Objectives:</b> The signal transducer and activator of transcription 4 (<i>STAT4</i>) gene encodes an important transcription factor that transmits signals induced by several cytokines associated with autoimmune diseases and has been identified as a susceptibility gene for numerous autoimmune disorders.
|
30666271 |
2018 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |