|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.
|
23028356 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Sixty-three RA patients were included.Nine genes (13 SNPs) were subsequently analyzed, including those coding for cytokines involved in synovitis (IL10, LTA, TGFβ1, TNF-α, TNF receptor II) and genes associated with RA susceptibility (-C5 TRAF1, STAT4, TNFAIP3 and PTPN22).
|
22129793 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
|
22446963 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TRAF1/C5 A allele and STAT4 TT genotype were significantly associated with RA severity.
|
22196377 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, rs7574865 and rs10181656, in STAT4, were associated with ACPA-positive RA in the Swedish study.
|
22753649 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the association of a common STAT4 haplotype with type 1 diabetes (T1D) as well as rheumatoid arthritis has been documented in Caucasians and Koreans.
|
22069275 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, in addition to the previously associated STAT4 alleles, variants at these three loci may contribute to RA not only among Europeans, but also among Asians.
|
21452313 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
With the exception of the major histocompatibility complex (MHC) and STAT4, no other rheumatoid arthritis (RA) linkage peak has been successfully fine-mapped to date.
|
21370227 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of STAT4 rs7574865 single nucleotide polymorphism (SNP) was performed in 140 patients affected with RA, 159 patients affected with AITDs and 200 healthy controls using TaqMan® allelic discrimination assay.
|
21418779 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings strongly suggest that STAT4 genetic polymorphisms are associated with RA in Northwestern Chinese Han population, and support the hypothesis of STAT4 gene polymorphisms increasing the risk for RA across major populations.
|
21683716 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
RA susceptibility genes (TRAF1/C5, STAT4 and HLA-DRB1-SE) may be involved in the regulation of lipid metabolism in RA patients, thus contributing to cardiovascular disease (CVD) risk and adverse outcome.
|
21398331 |
2011 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes.
|
20454450 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort.
|
20353580 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis confirms that the STAT4 rs7574865 polymorphism is associated with RA susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
19588142 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results do not show that the PTPN22, STAT4 and TRAF1/C5 gene polymorphisms may confer a direct risk of CV disease in patients with RA.
|
20822712 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Asian controls have significantly higher allele frequency (32%) for the minor T allele of STAT4 rs7574865 SNP than population of European origin (22%), however, there was no significant difference of ORs for RA and SLE by ethnicity.
|
19479340 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor.
|
19737838 |
2009 |