|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, having TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times (95% CI, 3.03-8.55) greater odds of asthma diagnosis at the highest B[a]P range, compared to the odds at the reference range.
|
28807506 |
2017 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.
|
26765219 |
2016 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
In conclusion, our studies led to identification of some key candidate genes, namely IRF2, IL6, IFNGR2, STAT4 and IL4RA that modulate genetic susceptibility to asthma in the Indian population.
|
25994869 |
2015 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
After correction for multiple comparisons, 7 SNPs in 6 genes (CARD25, TGFB1, LY96, ACAA1, DEFB1, and IFNG) were associated with asthma (adjusted p-value<0.02), while 5 SNPs in 3 different genes (CD80, STAT4, and IRAKI) were significantly associated with eczema (adjusted p-value < 0.02).
|
22192168 |
2012 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
OVA-challenged STAT4-/- mice exhibited elevated AHR and pulmonary eosinophilia.
|
21205293 |
2011 |
|
Asthma
|
0.290 |
Therapeutic
|
disease |
RGD |
20 +/- 1.75)%] were all significantly higher than those of the control group [(1.51 +/- 1.04) x 10(7)/L, (0.70 +/- 0.48)%] (P < 0.01); the total cell numbers in BALF, the absolute numbers of EOS and EOS% of RA groups [(14.89 +/- 2.35) x 10(7)/L, (4.70 +/- 0.82)%; (10.98 +/- 1.81) x 10(7)/L, (3.56 +/- 0.53)%] were all significantly lower than those of asthma group (P < 0.01); (2) The concentration of IL-4 in BALF of asthma group (25.70 +/- 7.36) was significantly higher than that of the control group (8.55 +/- 2.97) (P < 0.01); the concentration of IL-4 of BALF of RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly lower than that of asthma group (P < 0.01); the concentration of IL-12 of BALF of asthma group (16.10 +/- 3.38) was significantly lower than that of the control group (42.33 +/- 9.66) (P < 0.01); the concentration of IL-12 of BALF of the RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly higher than that of the asthma group (P < 0.01); (3) Immunohistochemistry and in situ hybridization showed that the protein content of STAT4 and the STAT4 mRNA expression around the bronchus of asthma group [(0.096 +/- 0.012), (0.098 +/- 0.011)] were lower than those of the control group [(0.216 +/- 0.034), (0.228 +/- 0.032)], while those of RA groups [(0.176 +/- 0.012), (0.185 +/- 0.023); (0.183 +/- 0.011), (0.201 +/- 0.019)] were all significantly higher than that of the asthma group (P < 0.01), the airway smooth muscle cells, the pulmonary arterial smooth muscle cells and endothelial cells were the chief expression cells; (4) the STAT4 and the STAT4mRNA expression around the bronchus had positive correlation with the concentration of IL-12 in BALF while had negative correlation with the concentration of IL-4, absolute numbers of EOS in BALF.
|
18211752 |
2007 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
LHGDN |
The STAT-4 T90089C polymorphisms were significantly associated with asthma in the dominant model (p=0.007).
|
17532201 |
2007 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
The STAT-4 T90089C polymorphisms were significantly associated with asthma in the dominant model (p=0.007).
|
17532201 |
2007 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
In an effort to discover additional polymorphism(s) in genes in which variant(s) have been implicated in asthma, we investigated the genetic polymorphisms in STAT4 to evaluate it as a potential candidate gene for a host genetic study of asthma.
|
15744455 |
2005 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
However, genomic DNA isolated from 91 patients with asthma or rheumatoid arthritis showed no evidence of mutations in the defined STAT4 essential promoter region.
|
16301617 |
2005 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
For STAT6 and STAT4, no significant association to asthma or serum total IgE levels was observed.
|
15637551 |
2005 |