|
Aggressive Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma.
|
12716366 |
2003 |
|
Aneuploidy
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
|
24976383 |
2014 |
|
Angiofibroma
|
0.010 |
Biomarker
|
disease |
LHGDN |
AURKA and MDM2 were identified as interesting novel amplified genes in juvenile angiofibromas.
|
17120309 |
2007 |
|
Angiofibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
AURKA and MDM2 were identified as interesting novel amplified genes in juvenile angiofibromas.
|
17120309 |
2007 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
The combination also reduces the growth of PDAC xenografts <i>in vivo</i> Mechanistically, it was found that inhibiting methyltransferases of the H3K9 pathway in cells, which are arrested in G<sub>2</sub>-M after targeting AURKA, decreases H3K9 methylation at centromeres, induces mitotic aberrations, triggers an aberrant mitotic check point response, and ultimately leads to mitotic catastrophe.
|
28442587 |
2017 |
|
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Thus, tumor hypoxia may trigger overexpression of STK15 observed in various tumors.
|
18562694 |
2008 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study identified the regulation of Linc00299, via miR-490-3p targeting Aurora kinase A (AURKA), on migration and proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) during atherosclerosis.
|
30734057 |
2019 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we identified a corresponding increase in Aurora Kinase A (AURKA) protein expression in epithelial cells from asthmatics compared to those from non-asthmatics.
|
28137284 |
2017 |
|
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, interactions between AURKA and AURKB stabilize and protect AURKA/B from degradation, and overexpression of SIX3 does not affect these interactions; SIX3 also acts as a tumor suppressor, and it increases p53 activity and expression at the post-translational level by the negative regulation of AURKA or AURKB, reduces the events of numerical centrosomal aberrations and misaligned chromosomes, and significantly inhibits the proliferation, invasion, and tumorigenesis of astrocytoma in vitro and in vivo.
|
28595628 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study identified the regulation of Linc00299, via miR-490-3p targeting Aurora kinase A (AURKA), on migration and proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) during atherosclerosis.
|
30734057 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Four ES-62 analogues were tested - 11a and 12b, previously shown to be active in mouse models of allergic and autoimmune disease and 16b and AIK-29/62 both of which are structurally related to 11a.
|
29802846 |
2018 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
To elucidate the function of Aurora2/BTAK/STK15 in NHL, Aurora2/BTAK/STK15 sense or antisense genes were transfected to B-cell lymphoma cell lines to generate overexpressed or under-regulated tumour cells.
|
12716366 |
2003 |
|
Basal-Like Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
JIMT-1 cell line was found as a possible in vitro model system for testing Aurora-A inhibitors, since it has been classified as basal-like breast cancer and here it showed both AURKA gene amplification and elevated mRNA expression.
|
20043089 |
2010 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
Applying STK15 FISH to benign urothelium of bladder cancer patients may help to identify patients at increased risk for adverse clinical outcome.
|
17786310 |
2007 |
|
Bladder Neoplasm
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we observed that some bladder tumor cell lines expressed more Aurora-A/STK15 than cultured normal urothelial cells and that Aurora-A/STK15 expression was higher in an immortalized E7 urothelial cell line having 20q amplification than in an E6 line lacking 20q amplification.
|
15547700 |
2004 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
STK15 protein was visualized by immunohistochemistry in 205 formalin-fixed, paraffin-embedded human bladder tumors.
|
12208897 |
2002 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
To test the hypothesis that common sequence variants in the cell cycle control pathway may affect bladder cancer susceptibility, the effects of a panel of 10 potential functional single nucleotide polymorphisms (SNPs) from 7 cell cycle control genes, P53, P21, P27, CDK4, CDK6, CCND1, and STK15, were evaluated on bladder cancer risk in a case-control study of 696 bladder cancer cases and 629 healthy controls.
|
18361427 |
2008 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
These findings implicate AURKA acting as an effective biomarker for BC detection and prognosis, as well as therapeutic target.
|
30547784 |
2018 |
|
Bladder Neoplasm
|
0.080 |
AlteredExpression
|
disease |
LHGDN |
Applying STK15 FISH to benign urothelium of bladder cancer patients may help to identify patients at increased risk for adverse clinical outcome.
|
17786310 |
2007 |
|
Bladder Neoplasm
|
0.080 |
AlteredExpression
|
disease |
LHGDN |
Forced overexpression of AURKA in urothelial cells induced amplification of centrosomes, chromosome missegregation, and aneuploidy, and natural overexpression was detectable in in situ lesions from patients with bladder cancer.
|
18812553 |
2008 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
These results implicate AURKA as an effective biomarker for bladder cancer detection as well as therapeutic target especially for its basal type.
|
28102366 |
2017 |
|
Bladder Neoplasm
|
0.080 |
Biomarker
|
disease |
BEFREE |
We evaluated Aurora kinase A, identified as an upregulated candidate molecule in bladder cancer, as a potential therapeutic target.
|
23403633 |
2013 |
|
Bladder Neoplasm
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Forced overexpression of AURKA in urothelial cells induced amplification of centrosomes, chromosome missegregation, and aneuploidy, and natural overexpression was detectable in in situ lesions from patients with bladder cancer.
|
18812553 |
2008 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Interestingly, we detected overexpression of STK15 mRNA in 60% of the analyzed brain tumours.
|
15547718 |
2004 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Remarkably, our data reveal a novel potential therapeutic strategy for targeting both the cytoplasmic and nuclear AURKA function to effectively eliminate BCSCs, so as to overcome both breast cancer and drug resistance.
|
28114286 |
2017 |