Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Immunocytochemical staining showed that the expression of LKB1 was significantly decreased in adenocarcinoma and mucinous adenocarcinoma tissues, and this reduced expression induced the invasion and metastasis of CRC.
|
30483811 |
2019 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Alterations characteristic of adenocarcinoma (EGFR, KRAS, ALK receptor tyrosine kinase [ALK], ROS1, and serine/threonine kinase 11 [STK11]) were detected in the LCC-AD subgroup but not in LCC-SqCC, whereas squamous-lineage alterations (phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha [PIK3CA], SRY-box 2 [SOX2], fibroblast growth factor receptor 1 [FGFR1], and AKT1) were detected in the LCC-SqCC subgroup but not in the LCC-AD group.
|
30978501 |
2019 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Instead, concurrent mutations in TP53 and STK11 were shown to confer poor survival in the KRAS-positive adenocarcinoma subgroup.
|
30885352 |
2019 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ion AmpliSeq Cancer Panel detected 9 potentially actionable variants in 29 adenocarcinomas that were wild type by the 8-gene panel testing (9 of 29, 31.0%) in the following genes: ERBB2 (3 of 29, 10.3%), STK11 (2 of 29, 6.8%), PTEN (2 of 29, 6.8%), FBXW7 (1 of 29, 3.4%), and BRAF G469A (1 of 29, 3.4%).
|
29219616 |
2018 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APC:T1556fs and STK11 mutations found in duodenal adenomas/ACs highlight the importance of proteins encoded by these genes in tumor development.
|
29525853 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The high level of cytoplasmic LKB1 expression was an independent risk factor for poor overall survival in patients with adenocarcinoma.
|
30033530 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
LKB1 inactivation occurs in a subset of esophageal adenocarcinomas and is sufficient to drive tumor cell proliferation.
|
29370903 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
LKB1 protein expression and Smad1 phosphorylation analysis in a cohort of non-small cell lung cancer patients demonstrated a negative correlation predominantly in a subset enriched in adenocarcinomas.
|
26701726 |
2016 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Taken together, our findings define new personalized therapeutic strategies that may be rapidly translated into clinical use for the treatment of KRAS/LKB1-mutant adenocarcinomas and squamous cell tumors.
|
26574479 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Multivariate analysis indicated that adenocarcinoma (P<0.05), lymph node metastasis (P<0.05), advanced TNM stage (P<0.001) and reduced expression of LKB1 (P<0.05) and Beclin1 (P<0.001) are all independent prognostic indicators for the survival of NSCLC patients.
|
25175672 |
2014 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For adenocarcinoma, remaining four epitypes were associated with unsupervised and supervised gene expression phenotypes, and differences in molecular features, including global hypomethylation, promoter hypermethylation, genomic instability, expression of proliferation-associated genes, and mutations in KRAS, TP53, KEAP1, SMARCA4, and STK11.
|
25278450 |
2014 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PJS is a rare hereditary disease, which may be associated with the development of poor outcome adenocarcinomas and LKB1-gene mutations.
|
24054548 |
2013 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The three most frequently altered genes in a subgroup of smokers with adenocarcinoma were EGFR (22.0%), STK11 (19.0%), and KRAS (12.0%).
|
22768234 |
2012 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Whereas CUL2 mRNA expression levels of greater than 1.7 was predictive for major response (p = 0.02) in adeno- and squamous cell carcinoma, STK11 was predominantly response predictive for adenocarcinomas.
|
20712528 |
2010 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.
|
18594528 |
2008 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
LKB1 modulates lung cancer differentiation and metastasis.
|
17676035 |
2007 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
LKB1 modulates lung cancer differentiation and metastasis.
|
17676035 |
2007 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Prevalence and specificity of LKB1 genetic alterations in lung cancers.
|
17384680 |
2007 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We sequenced the LKB1 gene in 22 lung cancer cell lines and 100 Japanese patients with lung cancer (including 81 adenocarcinomas, 14 squamous cell carcinomas and five other histological types) who had undergone curative pulmonary resection.
|
17711506 |
2007 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genotype-phenotype analysis did not yield any significant differences between patients carrying mutations in LKB1/STK11 versus those without mutations, even with respect to primary biliary adenocarcinoma.
|
17404884 |
2007 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Acquired mutations in LKB1 are rarely observed in most sporadic tumor types except for adenocarcinomas of the lung where up to 50% harbor inactivating mutations.
|
16822578 |
2006 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The inactivation of Stk11 in 27% (6/22) of IPMNs versus 7% (4/56) of pancreatic adenocarcinomas suggests genetic disparities in the pathogenesis of these closely related neoplasms.
|
12861065 |
2003 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Somatic mutations of the STK11 gene were confirmed in 6 (55%) of the 11 mucinous MDAs and 1 (5%) of the 19 mucinous adenocarcinomas, but not in the 5 nonmucinous adenocarcinomas, the 15 squamous cell carcinomas, nor the 5 endocervical glands with gastric metaplasia.
|
12533684 |
2003 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
|
12097271 |
2002 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
|
12097271 |
2002 |