STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Disease: Malignant tumor of cervix ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 GeneticVariation disease BEFREE The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. 30222967 2018
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 GeneticVariation disease BEFREE However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. 27546620 2017
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 AlteredExpression disease BEFREE Gene expression profiles of cervical cancer HeLa cells stably expressing LKB1 were analyzed by microarray. 24792998 2014
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 Biomarker disease BEFREE Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. 25155037 2014
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 Biomarker disease BEFREE Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. 24285539 2014
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 AlteredExpression disease BEFREE LKB1 expression and the integrity of LKB1-AMPK signaling were determined with immunoblot in 6 cervical cancer cell lines. 22735790 2012
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 GeneticVariation disease BEFREE Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. 21926085 2011
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.080 GeneticVariation disease BEFREE Somatic LKB1 mutations promote cervical cancer progression. 19340305 2009