STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE LKB1 loss exhibited a dramatic reduction on tumor burden and metastatic potential; in particular, OVCAR8-STK11KO tumors had evidence of extensive necrosis, apoptosis and hypoxia. 31744879 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE The signaling pathway activated by metformin (LKB1/AMPK/mTOR) is implicated in tumor suppression in ApcMin/+ mice via metformin-induced reduction in polyp burden, increased ratio of pAMPK/AMPK, decreased pmTOR/mTOR ratio, and decreased pS6Ser235/S6Ser235 ratio in polyps. 31818851 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE We created and phenotyped mouse models in which mutations in <i>Kras</i> and in the tumour suppressor gene liver kinase B1 (<i>Lkb1</i>/<i>Stk11</i>) are conditionally induced in pancreatic ducts using Cre-mediated gene recombination. 31154393 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE Importantly, the lack of effect in cells expressing wild-type LKB1, predicts that treatment of LKB1 mutated tumors with ERK inhibitors should have a favorable toxicity profile. 31634668 2020
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE Detailed phenotyping including tumor IHC and its correlation with comprehensive STK11 genotyping by full gene sequencing followed by large genomic rearrangement analysis was performed in an Indian PJS cohort. 30689838 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE None of STK11 mutated tumors (n = 7) expressed PD-L1. 30885341 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE The kinase LKB1 is a critical tumor suppressor in sporadic and familial human cancers, yet the mechanisms by which it suppresses tumor growth remain poorly understood. 31350327 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in apoptosis induction. 30863111 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 AlteredExpression group BEFREE Patients with LKB1 expression loss experienced significantly lower disease-free survival (DFS) (hazard ratio [HR], 1.287; 95% confidence interval [CI], 1.093 to 1.654; p=0.021) and overall survival (OS) (HR, 1.541; 95% CI, 1.197 to 1.932; p=0.002), compared to patients with LKB1 expressing expressing tumors. 30913862 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour suppressor. 31288625 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 AlteredExpression group BEFREE LKB1 expression was compared with tumour size, histological grade, axillary lymph node stage, ER, PgR, EGFR, HER2, HER3, HER4, BRCA1&2, p53, Ki67, Bcl2, Muc1, E-Cadherin, CD44, basal (CK5, CK5/6, CK14 and CK17) and luminal (CK7/8, CK18 and CK19) cytokeratins, MDM2 and MDM4, and correlated with long-term clinical outcome. 30696074 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Liver kinase B1 (LKB1), a tumor suppressor, is a central regulator of cell polarity and energy homeostasis. 30935996 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE According to our results, LCAL1 may physically interact with the catalytic subunit of tumor suppressor AMPK, prevent AMPK activation by upstream kinase (liver kinase B1), and thus inhibit the downstream AMPK signaling network. 30741368 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Liver kinase b1 (LKB1) is a tumor suppressor, and the inactivated mutation frequency of LKB1 in lung adenocarcinoma is ~20%. 31322182 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE NGS showed that the medullary component of this tumor had a novel STK11 p.G270W mutation, which was not present in the mucinous component. 31243107 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Serine-threonine kinase11 (STK11) is a tumor suppressor gene which plays a key role in regulating cell growth and apoptosis. 31712642 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Finally, we provide evidence that endogenous LKB1 is modified by SUMO in pre-clinical mouse models of HCC and clinical HCC, where LKB1 SUMOylation is higher in fast growing tumors. 30594553 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE Inactivating mutations of the tumor suppressor gene Liver Kinase B1 (<i>LKB1</i>) are frequently detected in non-small-cell lung cancer (NSCLC) and cervical carcinoma. 31781355 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE The tumor suppressor liver kinase B1 (LKB1) was revealed to be a potential target of miR-744, suggesting its potential mechanism of action. 30675291 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Co-occurring genomic alterations, particularly in tumour suppressor genes such as TP53 and LKB1 (also known as STK11), have emerged as core determinants of the molecular and clinical heterogeneity of oncogene-driven lung cancer subgroups through their effects on both tumour cell-intrinsic and non-cell-autonomous cancer hallmarks. 31406302 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 AlteredExpression group BEFREE Low LKB1 expression predicts shorter OS, worse tumour differentiation, larger tumours, earlier lymph node metastasis and more advanced TNM stage. 31383697 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE STK11 gene mutations may provide insights in the development of multiple cartilaginous tumors in enchondromatosis, this tumor suppressor gene having been shown in animal models to regulate both chondrocyte maturation and growth plate organization during development. 31240473 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 GeneticVariation group BEFREE Mutations in the LKB1 (also known as <i>STK11</i>) tumor suppressor are the third most frequent genetic alteration in non-small cell lung cancer (NSCLC). 31350328 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 AlteredExpression group BEFREE Thus, this study reveals HPD as a novel regulator of LKB1-AMPK signaling-mediated HDAC10 nuclear location, which contributes to G6PD expression in promoting tumor growth, which is a promising target for lung cancer treatment. 31285420 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.200 Biomarker group BEFREE Liver kinase B1 (LKB1) is a tumor suppressor that functions as master regulator of cell growth, metabolism, survival, and polarity. 31513784 2019