STK11, serine/threonine kinase 11, 6794

N. diseases: 231; N. variants: 115
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 Biomarker disease BEFREE LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. 20452353 2010
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 GeneticVariation disease BEFREE Germline inactivation of the gene LKB1/STK11 have been shown to cause Peutz-Jeghers syndrome (PJS) associated with a approximately 100-fold higher risk for the development of pancreatic cancer. 15331174 2004
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 Biomarker disease BEFREE By confocal microscopy as well as biochemical fractionation, we demonstrate that LKB1 is present in the nuclear and mitochondrial compartments of pancreatic cancer cells. 14511408 2004
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 CausalMutation disease CLINVAR In a PJS patient having a germline splice site mutation in the STK11/LKB1 gene, sequencing analysis of an intestinal polyp and pancreatic cancer from this patient revealed loss of the wild-type allele of the STK11/LKB1 gene in the cancer. 10362809 1999
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 GeneticVariation disease BEFREE Germline mutations in BRCA2 have been shown to predispose to both breast and pancreatic cancer, germline mutations in p16 to melanoma and pancreatic cancer (the FAMMM syndrome), and genetic mutations in STK11/LKB1 to pancreatic cancer in patients with the Peutz-Jeghers Syndrome (PJS). 10436789 1999
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 GeneticVariation disease BEFREE In a PJS patient having a germline splice site mutation in the STK11/LKB1 gene, sequencing analysis of an intestinal polyp and pancreatic cancer from this patient revealed loss of the wild-type allele of the STK11/LKB1 gene in the cancer. 10362809 1999
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 GenomicAlterations disease CGI
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma
0.450 CausalMutation disease CGI