Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors. 27705915 2016
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study. 23415580 2014
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways. 23451056 2013
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. 19681070 2009
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. 18172296 2008
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. 16707622 2006
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. 15987703 2005
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. 16357136 2005
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. 15480979 2004
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN The LKB1 tumor suppressor negatively regulates mTOR signaling. 15261145 2004
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. 12865922 2003
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. 12226664 2002
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. 12218179 2002
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease MGD Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. 12060709 2002
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. 9425897 1998
CUI: C0265323
Disease: Peutz-Jeghers polyps of small bowel
Peutz-Jeghers polyps of small bowel
0.500 Biomarker disease CLINGEN Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. 9288765 1997