STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 AlteredExpression disease BEFREE Loss of tumoral LKB1 protein expression, constitutes an adverse prognostic factor in patients with operable CC. 30913862 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 Biomarker disease BEFREE Mechanistic studies were performed in two each of p53 wild-type (HCT116, LoVo) and p53-mutated (SW480, HT29) colon cancer cells to explore whether LKB1 loss could be deregulated by NKX2-1-mediated p53 pathway. 24879590 2014
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 AlteredExpression disease BEFREE The knockdown of LKB1 enhanced cell migration and PAK1 activity in human colon cancer HCT116 cells, whereas forced expression of LKB1 in Lkb1-null mouse embryonic fibroblasts suppressed PAK1 activity and PAK1-mediated cell migration simultaneously. 20400510 2010
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 Biomarker disease BEFREE To clarify the role of LKB1 in colon cancer, we scrutinized 50 left-sided Korean and Finnish specimens.No somatic mutations were found. 10676634 2000
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 GeneticVariation disease BEFREE STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer. 9809980 1998
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.060 Biomarker disease BEFREE This results indicate that STK11 is a tumor suppressor gene and that genetic changes of STK11 play an important role in left-sided colon cancer carcinogenesis. 9731485 1998