STK11, serine/threonine kinase 11, 6794

N. diseases: 231; N. variants: 115
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 AlteredExpression disease BEFREE LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. 24879590 2015
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 GeneticVariation disease BEFREE We have screened 37 JPS families/cases without known SMAD4 mutations, 10 Peutz-Jeghers cases without known LKB1 mutations and 49 sporadic colorectal cancers for mutations in CDX2. 11355940 2001
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 PosttranslationalModification disease BEFREE 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. 10896921 2000
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 Biomarker disease BEFREE LKB1 involvement in distal colorectal cancer is not common. 10676634 2000
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 PosttranslationalModification disease BEFREE Our data indicate the heterogeneity of PJS and the infrequent involvement of the STK11 gene in colorectal cancer. 9809980 1998
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 GeneticVariation disease UNIPROT Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer. 9731485 1998
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.550 Biomarker disease GENOMICS_ENGLAND