STK11, serine/threonine kinase 11, 6794

N. diseases: 372; N. variants: 145
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation disease BEFREE The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. 30222967 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation disease BEFREE However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. 27546620 2017
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker disease BEFREE Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. 24285539 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression disease BEFREE Gene expression profiles of cervical cancer HeLa cells stably expressing LKB1 were analyzed by microarray. 24792998 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker disease BEFREE Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. 25155037 2014
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression disease BEFREE LKB1 expression and the integrity of LKB1-AMPK signaling were determined with immunoblot in 6 cervical cancer cell lines. 22735790 2012
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation disease BEFREE Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. 21926085 2011
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 AlteredExpression disease BEFREE Thus, homozygous deletions affecting LKB1 in cervical cancers may generate multiple fusion transcripts involving LKB1, SBNO2, and c19orf26. 20193846 2010
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation disease BEFREE Somatic LKB1 mutations promote cervical cancer progression. 19340305 2009
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker disease BEFREE The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers. 19724060 2009
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 GeneticVariation disease UNIPROT
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.500 Biomarker disease HPO