TBXT, T-box transcription factor T, 6862

N. diseases: 41; N. variants: 4
Disease: Chordoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 AlteredExpression disease BEFREE These systematic approaches reveal that the developmental transcription factor T (brachyury; TBXT) is the top selectively essential gene in chordoma, and that transcriptional cyclin-dependent kinase (CDK) inhibitors targeting CDK7/12/13 and CDK9 potently suppress chordoma cell proliferation. 30664779 2019
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 Biomarker disease CTD_human A common single-nucleotide variant in T is strongly associated with chordoma. 23064415 2012
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 SusceptibilityMutation disease ORPHANET A common single-nucleotide variant in T is strongly associated with chordoma. 23064415 2012
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 Biomarker disease GENOMICS_ENGLAND A common single-nucleotide variant in T is strongly associated with chordoma. 23064415 2012
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 Biomarker disease GENOMICS_ENGLAND T (brachyury) gene duplication confers major susceptibility to familial chordoma. 19801981 2009
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 SusceptibilityMutation disease ORPHANET T (brachyury) gene duplication confers major susceptibility to familial chordoma. 19801981 2009
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 Biomarker disease CTD_human T (brachyury) gene duplication confers major susceptibility to familial chordoma. 19801981 2009
CUI: C0008487
Disease: Chordoma
Chordoma 		0.620 AlteredExpression disease LHGDN Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. 18301055 2008