TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Disease: Bradycardia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.500 Biomarker phenotype CTD_human Facilitation by substance P and inhibition by (+)-tubocurarine of the 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats. 8960879 1996
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.500 Biomarker phenotype RGD Microinjection of SP (1 ng) or NKA (10-100 ng) into the NTS caused prompt, transient hypotension and bradycardia, suggesting that SP and NKA may be neurotransmitters of the baroreceptor reflex in the NTS. 2471579 1989
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.500 Biomarker phenotype CTD_human The most sensitive sites where application of SP into the NTS evoked dose-dependent hypotension and bradycardia were at the level of the posterior tip of the area postrema (zero level) and at the level of the obex. 2445440 1987