TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group PSYGENET Method We investigated the associations between SSEPs and polymorphisms within candidate genes of the serotonergic, GABAergic as well as the substance P system in subjects at high risk for affective disorders. 22225676 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE Method We investigated the associations between SSEPs and polymorphisms within candidate genes of the serotonergic, GABAergic as well as the substance P system in subjects at high risk for affective disorders. 22225676 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE In this study, we used macroarrays to investigate the differential gene expression profile induced by SP, particularly of genes which have been shown to be involved in the pathophysiology of affective disorders. 16806114 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group PSYGENET In this study, we used macroarrays to investigate the differential gene expression profile induced by SP, particularly of genes which have been shown to be involved in the pathophysiology of affective disorders. 16806114 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE The results confirm an involvement of the tachykinins in psychiatric disorders, suggesting there is a generalized impairment of the SP system in the amygdala in mood disorders and schizophrenia rather than this being a disease-related phenomenon. 15845098 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group PSYGENET Results from preclinical and human studies implicate SP and its pathway in the pathophysiology of mood disorders. 15927090 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group PSYGENET The results confirm an involvement of the tachykinins in psychiatric disorders, suggesting there is a generalized impairment of the SP system in the amygdala in mood disorders and schizophrenia rather than this being a disease-related phenomenon. 15845098 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE Results from preclinical and human studies implicate SP and its pathway in the pathophysiology of mood disorders. 15927090 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE This review focuses on the role of SP in the pathogenesis of affective disorders. 12692775 2003
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group PSYGENET More recently, the neuropeptide substance P (SP) and its receptor (the neurokinin-1 receptor [NK1R]) have been implicated in the pathophysiology of affective disorders, including depression. 12562138 2002
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 GeneticVariation group BEFREE These results suggest that the ACE I/D polymorphism is one of the genetic factors for an interindividual variability of brain SP levels, and that the ACE polymorphism may contribute to the susceptibility to affective disorders. 8931914 1996
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.370 Biomarker group BEFREE Comparison of the frequency of the genotypes deduced from the polymorphic alleles of gastrin-releasing peptide, NPY, somatostatin and substance P in normals vs patients with either AD or schizophrenia suggests the absence of association. 2894462 1987