TAC1, tachykinin precursor 1, 6863

N. diseases: 478; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype BEFREE This SP(1-7) peptidomimetic was as effective as SP(1-7) in alleviating mechanical allodynia in mice. 29745331 2018
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype BEFREE Taken together, the results revealed beneficial effects of TUS on oxaliplatin-induced mechanical hyperalgesia and cold allodynia and suggested involvement of TUS biochemicals in suppressing TRPM8 in DRG and SP in spinal cords. 28433438 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype BEFREE We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. 27956715 2017
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys. 19231294 2009
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. 18234883 2008
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves. 16259764 2005
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human The antinociception caused by the mixture of compounds seems to involve mechanisms independent of opioid, alpha-adrenergic, serotoninergic, and nitrergic system mediation, since it was not affected by naloxone, prazosin, yohimbine, DL-p-chlorophenylalanine methyl ester, or L-arginine.Interestingly, the i.p. administration of alpha,beta-amyrin reduced the mechanical hyperalgesia produced by i.pl. injection of carrageenan, capsaicin, bradykinin, substance P, prostaglandin E2, 8-Br-cAMP, and TPA in rats. 15626726 2005
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain. 12787826 2003
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Hyperalgesia during opioid abstinence: mediation by glutamate and substance p. 12351280 2002
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester. 10499367 1999
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). 9714424 1998
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.330 Biomarker phenotype CTD_human Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors. 8864563 1996