TACR1, tachykinin receptor 1, 6869

N. diseases: 217; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 GeneticVariation disease BEFREE To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence. 24817687 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease PSYGENET After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration. 24705689 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease PSYGENET The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders. 24817687 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease PSYGENET Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and stress-induced alcohol relapse in rodents, while TACR1 variation is associated with alcoholism in humans. 23419547 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 GeneticVariation disease BEFREE Each of the 5 SNPs in the TACR1 gene that was significantly related to AD severity in the SAGE data set and/or the BOLD response to the craving task is near the 3' or 5' areas of the gene and may therefore be near mutations with potential functional significance. 23078527 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease PSYGENET Each of the 5 SNPs in the TACR1 gene that was significantly related to AD severity in the SAGE data set and/or the BOLD response to the craving task is near the 3' or 5' areas of the gene and may therefore be near mutations with potential functional significance. 23078527 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 GeneticVariation disease BEFREE Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease CTD_human Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease PSYGENET Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 GeneticVariation disease BEFREE Taken together, we conclude that polymorphisms of NK1R are significantly associated with the development of AD in Caucasian individuals. 19553914 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.550 Biomarker disease BEFREE Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism. 18276852 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 Biomarker disease PSYGENET The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders. 24817687 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 Biomarker disease BEFREE The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders. 24817687 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 GeneticVariation disease BEFREE Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 Biomarker disease CTD_human Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 Biomarker disease PSYGENET Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD. 19204064 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.520 Biomarker disease PSYGENET Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. 19415819 2009
CUI: C0600467
Disease: Neurogenic Inflammation
Neurogenic Inflammation 		0.500 Biomarker disease CTD_human Proliferation of sensory C-fibers and subsequent neurogenic inflammation in rat airway induced by inhaled lipopolysaccharide. 21570423 2011
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.500 Biomarker disease CTD_human NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. 19204064 2010
CUI: C0600467
Disease: Neurogenic Inflammation
Neurogenic Inflammation 		0.500 Biomarker disease RGD These findings suggest that SP acts via the NK-1 receptor to provoke neurogenic inflammation, oxidative stress, and ICAM-1 expression after OSE in rats. 18326823 2008
CUI: C0600467
Disease: Neurogenic Inflammation
Neurogenic Inflammation 		0.500 Biomarker disease CTD_human Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation. 17257769 2007
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.500 Biomarker disease MGD Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. 11433347 2001
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.500 Biomarker disease MGD Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. 9748515 1998
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 Biomarker phenotype BEFREE In contrast, NK1R antagonism decelerated lesional development and improved hyperalgesia. 30689856 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.330 Biomarker phenotype BEFREE Emerging evidence has suggested that neurokinin 1 receptor (NK1R) is important in the development of visceral pain and hyperalgesia, however, whether NK1R exists in the CSF‑CN and its exact role in visceral pain remain to be fully elucidated. 28440440 2017