KLF9, Kruppel like factor 9, 687

N. diseases: 77; N. variants: 7
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE Moreover, in the biological function study, KLF9 was further validated to inhibit the growth, migration, and metastasis of ESCC cells in vitro and in vivo. 25641762 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE Functionally, KLF9 transcriptionally down-regulated MMP9 expression and inhibited the metastasis of breast cancer cells. 29107105 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE KLF9 overexpression significantly stimulated the proliferation and metastasis of MGC-803 and BGC-823 cells. 30746617 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE To address this question, we crossed mice-bearing knock-out of Klf9, an ubiquitous transcriptional regulator of oxidative stress, with two conditional melanocytic mouse models: Braf<sup>CA</sup> mice, where Braf<sup>V600E</sup> causes premalignant melanocytic hyperplasia, and Braf<sup>CA</sup>/Pten<sup>-/-</sup> mice, where Braf<sup>V600E</sup> and loss of Pten induce primary melanomas and metastases. 30664687 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28. 30913394 2019