TAL2, TAL bHLH transcription factor 2, 6887

N. diseases: 6; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 AlteredExpression group BEFREE A positive association was found between ERCC1 and XPB expression (r=0.53, p<0.0001) and between TAL2 and EGF expression (r=0.817, p<0.0001) suggesting the existence of gene linkage in these tumors. 21971700 2012
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE Our data support the involvement of 2 distinct mechanisms: translocations involving LMO2, TAL2, and TAL1 in T cell acute lymphoblastic leukemia (T-ALL), are compatible with illegitimate V(D)J recombination between a TCR locus and a proto-oncogene locus bearing a fortuitous but functional recombination site (type 1); in contrast, translocations involving BCL1 and BCL2 in B cell non-Hodgkin's lymphomas (B-NHL), are compatible with a process in which only the IgH locus breaks are mediated by V(D)J recombination (type 2). 11781368 2002
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia
0.020 Biomarker disease BEFREE tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix-loop-helix transcription factors and were originally isolated from the breakpoints of chromosomal translocations in human T-cell leukemia cell lines. tal-1 is expressed not only in hematopoietic cells but also in several endothelial structures and the central nervous system during development. 9931488 1999
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE Taken together, the properties of TAL2 evaluated here broadly resemble those described previously for TAL1, and therefore support the idea that both proteins promote T-ALL by a common mechanism. 8152805 1994
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 GeneticVariation disease BEFREE The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. 8142619 1993
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE The cDNA sequence of SCL/tal encodes a basic helix-loop-helix (bHLH) protein with regions of marked homology to lyl-1 and tal-2, two other bHLH proteins involved in T-ALL chromosomal translocations. 1450410 1992
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 GeneticVariation disease BEFREE TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). 1763056 1991
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia
0.020 AlteredExpression disease BEFREE TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. 1763056 1991
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease HPO
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human
Childhood Acute Lymphoblastic Leukemia
0.300 Biomarker disease CTD_human
CUI: C0023453
Disease: L2 Acute Lymphoblastic Leukemia
L2 Acute Lymphoblastic Leukemia
0.300 Biomarker disease CTD_human