Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE The cDNA sequence of SCL/tal encodes a basic helix-loop-helix (bHLH) protein with regions of marked homology to lyl-1 and tal-2, two other bHLH proteins involved in T-ALL chromosomal translocations. 1450410 1992
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 GeneticVariation disease BEFREE The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. 8142619 1993
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE Taken together, the properties of TAL2 evaluated here broadly resemble those described previously for TAL1, and therefore support the idea that both proteins promote T-ALL by a common mechanism. 8152805 1994
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 Biomarker disease BEFREE Our data support the involvement of 2 distinct mechanisms: translocations involving LMO2, TAL2, and TAL1 in T cell acute lymphoblastic leukemia (T-ALL), are compatible with illegitimate V(D)J recombination between a TCR locus and a proto-oncogene locus bearing a fortuitous but functional recombination site (type 1); in contrast, translocations involving BCL1 and BCL2 in B cell non-Hodgkin's lymphomas (B-NHL), are compatible with a process in which only the IgH locus breaks are mediated by V(D)J recombination (type 2). 11781368 2002
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.050 GeneticVariation disease BEFREE TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). 1763056 1991