Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have previously shown that Tbx1 heterozygous mice have reduced prepulse inhibition, a behavioral abnormality that is associated with 22q11.2DS and nonsyndromic schizophrenia.
|
27005988 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Velocardiofacial (VCFS; 22q11.2 deletion) syndrome is a genetic disorder that results from a hemizygous deletion of the q11.2 region on chromosome 22, and is associated with greatly increased risk for psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia.
|
25325218 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Velocardiofacial (VCFS; 22q11.2 deletion) syndrome is a genetic disorder that results from a hemizygous deletion of the q11.2 region on chromosome 22, and is associated with greatly increased risk for psychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia.
|
25325218 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Deletions at 1q21.1, 3q29, 15q11.2, 15q13.1 and 22q11.2 (VCFS region), and duplications at 16p11.2 were found significantly more often in schizophrenia cases, compared with the WTCCC reference set.
|
22130109 |
2012 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Deletions at 1q21.1, 3q29, 15q11.2, 15q13.1 and 22q11.2 (VCFS region), and duplications at 16p11.2 were found significantly more often in schizophrenia cases, compared with the WTCCC reference set.
|
22130109 |
2012 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Mapping cortical morphology in youth with velocardiofacial (22q11.2 deletion) syndrome.
|
21334567 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using iPSCs derived from three schizophrenia (SZ) patients, one of whom has 22q11.2del (velocardiofacial syndrome; VCFS), the authors developed a culture system to study SZ on a molecular and cellular level.
|
21797804 |
2011 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Using iPSCs derived from three schizophrenia (SZ) patients, one of whom has 22q11.2del (velocardiofacial syndrome; VCFS), the authors developed a culture system to study SZ on a molecular and cellular level.
|
21797804 |
2011 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
PSYGENET |
First, we found evidence for a male-specific genotypic association (P = 0.00017) TBX1/GNB1L in 662 schizophrenia cases and 1416 controls from the UK.
|
18003636 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In mice, hemizygous deletion of either Tbx1 or Gnb1l can cause deficits in pre-pulse inhibition, a sensory motor gating defect which is associated with schizophrenia.
|
18003636 |
2008 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the genetic polymorphisms within TBX1 do not confer an increased susceptibility to schizophrenia in the Chinese population.
|
17850965 |
2007 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.
|
16684884 |
2006 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We evaluated the Nogo-66 receptor gene (RTN4R), which maps within the DGS/VCFS critical region, as a potential candidate for schizophrenia susceptibility.
|
15532024 |
2004 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the PCQAP gene, which maps within the DGS/VCFS interval, as a potential candidate for schizophrenia susceptibility.
|
12497610 |
2003 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a complementary approach we also attempted to define the location of a schizophrenia susceptibility locus more precisely by performing association mapping using seven microsatellites spanning the VCFS region with an average inter-marker distance of 450 kb.
|
12476324 |
2002 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the UFD1L gene, mapping within the DGS/VCFS region, as a potential candidate for schizophrenia susceptibility.
|
11496370 |
2001 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mapping of the human adenosine A2a receptor gene: relationship to potential schizophrenia loci on chromosome 22q and exclusion from the CATCH 22 region.
|
9050917 |
1997 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|