VERTEBRAL ANOMALIES AND VARIABLE ENDOCRINE AND T-CELL DYSFUNCTION
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.
|
29726930 |
2018 |
VERTEBRAL ANOMALIES AND VARIABLE ENDOCRINE AND T-CELL DYSFUNCTION
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Neuroblastoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
To elucidate the underlying cellular mechanism of the TBX2-mediated repression of ADAM10 gene expression, we performed overexpression, RNAi-mediated knockdown and pharmacological inhibition studies in the human neuroblastoma cell line SH-SY5Y.
|
30599067 |
2019 |
Neuroblastoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
We then used genome-wide chromatin-immunoprecipitation coupled to high-throughput sequencing analysis to demonstrate that a small number of essential transcription factors-MYCN, HAND2, ISL1, PHOX2B, GATA3, and TBX2-are members of the transcriptional core regulatory circuitry (CRC) that maintains cell state in MYCN-amplified neuroblastoma.
|
30127528 |
2018 |
Neuroblastoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
We then used genome-wide chromatin-immunoprecipitation coupled to high-throughput sequencing analysis to demonstrate that a small number of essential transcription factors-MYCN, HAND2, ISL1, PHOX2B, GATA3, and TBX2-are members of the transcriptional core regulatory circuitry (CRC) that maintains cell state in MYCN-amplified neuroblastoma.
|
30127528 |
2018 |
Neuroblastoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we provide insight into the role of the TBX2 CRC gene in transcriptional dependency of neuroblastoma cells warranting clinical trials using BET and CDK7 inhibitors.
|
30451831 |
2018 |
Hypertensive disease
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
Hypertensive disease
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
|
27618447 |
2016 |
Hypertensive disease
|
0.110 |
Biomarker
|
group |
BEFREE |
The role of TBX2 and TBX4 in pulmonary hypertension warrants investigation.
|
21271665 |
2011 |
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
|
30604766 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TBX2 overexpression correlated with tumor invasion, advanced tumor node metastasis stage and presence of lymph node metastasis.
|
30651856 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we showed that the TBX2 subfamily genes play a critical tumor suppressor role in lung cancer pathogenesis through regulating its methylating pattern, making them putative candidates for epigenetic therapy in LUAD.
|
30425966 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma.
|
29719592 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The enriched genes included MMP9, SERPINE2, CAV1, KRT14, and RASA3 in basal tumors, and PPARG, LY6E, CTSE, CDK3, and TBX2 in luminal tumors.
|
30089113 |
2018 |
Chloride measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
Potassium measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
Mean blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
Fibroblast Growth Factor 23 Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.
|
30217807 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
At the molecular level, we discovered that expressions of several tumor suppressor genes, including <i>p21, p27</i>, <i>phosphatase with tensin homology (PTEN)</i> and <i>E-Cadherin</i>, were increased dramatically after TBX2 knockdown in above NPC cells.
|
28881763 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Blocking endogenous TBX2 expression in PC3 and ARCaP<sub>M</sub> prostate cancer cell models using a dominant-negative construct resulted in decreased tumor cell proliferation, colony formation, and invasion <i>in vitro</i> Blocking endogenous TBX2 in human prostate cancer mouse xenografts decreased invasion and abrogation of bone and soft tissue metastasis.
|
28108510 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results indicated that the expression rates of TBX2 were significantly increased in the cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade.
|
28849151 |
2017 |
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |