TCF4, transcription factor 4, 6925

N. diseases: 378; N. variants: 111
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease PSYGENET We investigated the expression levels of miR-137 and three candidate target genes (ZNF804A, CACNA1C, TCF4) in the DLPFC of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (CTR), 7 schizophrenia (SZ), 9 bipolar disorder (BD)) collected at the UCI brain bank; and (2) 99 subjects (33 CTR, 35 SZ, 31 BD) obtained from the Stanley Medical Research Institute (SMRI). 23786914 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease BEFREE We investigated the expression levels of miR-137 and three candidate target genes (ZNF804A, CACNA1C, TCF4) in the DLPFC of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (CTR), 7 schizophrenia (SZ), 9 bipolar disorder (BD)) collected at the UCI brain bank; and (2) 99 subjects (33 CTR, 35 SZ, 31 BD) obtained from the Stanley Medical Research Institute (SMRI). 23786914 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease PSYGENET Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci ERDA-1, SEF2-1b, MAB21L or KCNN3 influence susceptibility to BPAD in our sample. 11526470 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease PSYGENET Transmission of bipolar disorder may be characterized by anticipation and parent-of-origin effect, and extended CTG repeat at SEF2-1B gene was identified from a bipolar patient. 11377748 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 GeneticVariation disease BEFREE Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci ERDA-1, SEF2-1b, MAB21L or KCNN3 influence susceptibility to BPAD in our sample. 11526470 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease PSYGENET Using RED, we have identified a BPAD individual with a very large CAG/CTG repeat that is not due to expansion at SEF2-1B or ERDA1. 10712198 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease PSYGENET At present no strong evidence exists that large repeat alleles at either SEF2-1B or ERDA1 are involved in the etiology of schizophrenia or bipolar disorder. 10813808 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 Biomarker disease BEFREE At present no strong evidence exists that large repeat alleles at either SEF2-1B or ERDA1 are involved in the etiology of schizophrenia or bipolar disorder. 10813808 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 GeneticVariation disease BEFREE Using RED, we have identified a BPAD individual with a very large CAG/CTG repeat that is not due to expansion at SEF2-1B or ERDA1. 10712198 2000
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.450 GeneticVariation disease BEFREE We observed no increase in frequency of larger alleles (>37 repeats) in affected individuals at SEF2-1B (BPAD: P=0.95, n= 100; SCZ: P=0.61, n=97) or at ERDA1 (BPAD: P= 0.4, n = 101; SCZ: P= 0.05, n = 151, with larger alleles more frequent in controls). 10395212 1999