TBX3, T-box transcription factor 3, 6926

N. diseases: 179; N. variants: 12
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 Biomarker group BEFREE We demonstrate that Tbx3 is directly repressed by miR-206, and that this repression of Tbx3 is necessary for miR-206 to inhibit breast tumour cell proliferation and invasion, and decrease the cancer stem cell population. 27100732 2016
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 AlteredExpression group BEFREE TBX2 is preferentially amplified in BRCA1/2-associated breast cancers and TBX3 overexpression has been associated with advanced stage disease and estrogen-receptor-positive breast tumors. 23624936 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 Biomarker group CTD_human Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. 21098263 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 Biomarker group LHGDN TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases. 18245468 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 AlteredExpression group LHGDN Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients. 16049973 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 AlteredExpression group LHGDN TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines. 15289316 2004