HNF1A, HNF1 homeobox A, 6927

N. diseases: 292; N. variants: 105
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE The HNF1A mutation p.Pro409His can be considered a mild variant that confers a moderate risk of type 2 diabetes mellitus in heterozygous carriers. 30963309 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Furthermore, hepatocyte nuclear factor 1‑alpha (HNF1A), signal transducer and activator of transcription 3 (STAT3) and glucocorticoid receptor (GR) were key transcription factors in T2DM. 31524257 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Diagnosis of hepatocellular adenoma in men before onset of diabetes in HNF1A-MODY: Watch out for winkers. 31483937 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Concentration of hsCRP was lowest in HNF1A MODY (0.51 mg/l) and highest in type 2 diabetes (1.33 mg/l). 30778899 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes. 30455330 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE In HNF4A-MODY and HNF1A-MODY patients, normal or even increased insulin sensitivity together with glucose-independent mechanism of action of the first-line therapy - sulphonylurea derivatives - often leads to hypoglycemia, even at the much lower dose used in type 2 diabetes. 31682881 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE We hypothesized that common variants at the <i>HNF1A</i> locus (rs1169288 [rs1169288" genes_norm="6927">I27L], rs1800574 [rs1800574" genes_norm="6927">A98V]), which are associated with type 2 diabetes susceptibility, may modify age at diabetes diagnosis in individuals with HNF1A-MODY. 29895593 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE High-sensitivity C-reactive protein (hs-CRP) has shown promise as a biomarker to differentiate hepatic nuclear factor 1 alpha (<i>HNF1A</i>)-MODY from type 2 diabetes. 30181854 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE This study aimed to investigate differences in serum miR-122 levels in Chinese patients with different forms of diabetes, including T2DM, type 1 diabetes (T1DM), HNF1A variant-induced diabetes (HNF1A-DM), glucokinase variant-induced diabetes (GCK-DM), and mitochondrial A3243G mutation-induced diabetes (MDM). 30155490 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE This study demonstrated that the common HNF1A diplotype of three risk variants may be an independent risk factor for the development of DR resulting from poor glycemic control in normal-weight patients with T2DM. 27445006 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE The HNF1A variant p.Ala180Val does not seem to cause MODY3, although it may confer risk for type 2 diabetes mellitus. 28934671 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Post-hoc analysis revealed significant differences in mean glucose to creatinine ratio change between type 2 diabetes and each monogenic diabetes in response to dapagliflozin (p = 0.02, p = 0.003 for HNF1-A and GCK MODY, respectively), but not between the two MODY forms (p = 0.7231). 28593615 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population. 27899486 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Clinical application of ACMG-AMP guidelines in HNF1A and GCK variants in a cohort of MODY families. 28170077 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE MODY3 experienced a larger decrease in the ratio of NEFA to insulin (NEFA 30-0 / insulin 30-0: -39 [-78; -30] x104) in the early post-prandial period (0-30 minutes) compared to controls and to T2D (-2.0 [-0.6; -6.4] x104; P<0.05). 28493909 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE SLC5A2 and HNF1A mutations partially explain renal glycosuria in patients with T2DM. 28324025 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Overall, our results showed that LADA is genetically more similar to T1D, with the exception of an association at the T2D HNF1A locus. 28438156 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Successful maintenance on sulphonylurea therapy and low diabetes complication rates in a HNF1A-MODY cohort. 26479152 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus. 27807544 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Therefore one family member had classical type 2 diabetes including metabolic syndrome aggravated by a genetic predisposition in the form of HNF1A-MODY. 27142837 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE Tcf7 (in mice) or TCF7 (in humans) levels are lower in islets taken from diabetic mice and in humans with type 2 diabetes; knockdown of TCF7 in human and mouse islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury, whereas restoring TCF1 levels in beta cells from Gipr(-/-βCell) mice lowers the number of apoptotic cells compared to that seen in MIP-Cre controls. 26642437 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Our results show that mutations in HNF4A and HNF1A genes might account for this early-onset inherited type 2 diabetes. 26981542 2016