|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
B-cell lymphoma-2-associated transcription factor 1 is overexpressed and contributes to sorafenib resistance in hepatocellular carcinoma.
|
31237058 |
2019 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Here, we report that the combination of hepatocyte nuclear factor 1A (HNF1A), HNF4A and forkhead box protein A3 (FOXA3) synergistically reprograms hepatocellular carcinoma (HCC) cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).
|
30560924 |
2019 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
From the literature, 2 of 146 (1.4%) hepatocellular carcinomas had HNF1A mutations, and both arose in a background of adenomatosis.
|
30121369 |
2019 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Heat Shock Protein 90α-Dependent B-Cell-2-Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto-Oncogene c-MYC mRNA Stability.
|
30015413 |
2019 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Scientific research over the period of three decades has reported it as an important player in various liver malignancies such as hepatocellular cancers (HCCs), hepatocellular adenoma (HA), and a more specific HNF-1α-inactivated human hepatocellular adenoma (H-HCAs).
|
31685031 |
2019 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Among these lncRNAs, the expression levels of HNF1A-AS1 were notably correlated with HNF1α levels in HCC cells and human HCC tissues.
|
29466992 |
2018 |
|
Liver carcinoma
|
0.800 |
Therapeutic
|
disease |
RGD |
Among these lncRNAs, the expression levels of HNF1A-AS1 were notably correlated with HNF1α levels in HCC cells and human HCC tissues.
|
29466992 |
2018 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In this study, the point mutation of HNF1α gene with c.A1532 > T/p.Q511L was identified in an HCC patient by exon-capture high-throughput sequencing.
|
29101032 |
2018 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
However, our present data demonstrated that single transduction of HNF4A or HNF1A had only a limited effect on suppression of HCC cell proliferation.
|
30220099 |
2018 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma.
|
30155490 |
2018 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our previous studies have demonstrated the therapeutic effects of HNF1α on hepatic fibrosis and hepatocellular carcinoma (HCC) in animals.
|
28547778 |
2017 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Further analyses revealed a key role of ERK leading to increased phosphorylation of p90-ribosomal S6 kinase (RSK) and a concomitant activation of ETS-like transcription factor-1(ELK1) and Death Receptor protein-5 (DR5) in HCC.
|
29263422 |
2017 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The expression in HA was variable and differed between molecular subtypes of this neoplasm: inflammatory and HNF1A mutation-associated type are characterized by overexpression of c-MET to an extent comparable with poorly-differentiated HCC, whereas Wnt/β-catenin dysfunction-associated type lacks overexpression, and the amount of c-MET protein accumulated in its cells is similar to the levels in non-neoplastic tissue and well- to moderately-differentiated HCC.
|
29256857 |
2017 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Thus, we identified a pathway in which TNFα-NF-κB signaling switches off negative regulation by suppressing HNF-1α-mediated expression of miR-194, revealing insight into the mechanisms linking inflammatory pathways, miRNA, and HCC metastasis.
|
26221053 |
2015 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Mutation analysis of HNF1A [encoding hepatocyte nuclear factor 1 (HNF1)α] was performed for L-FABP-negative HCC cases.
|
25516669 |
2014 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Key features include metabolic alterations (induced by defects in HNF1A), oncogene-induced inflammation (activation of JAK-STAT signaling in inflammatory adenomas), and an association between activation of Wnt/β-catenin signaling and progression of HCAs in hepatocellular carcinomas.
|
23485860 |
2013 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
HJV promoter analysis revealed potential HNF-1α and snail-binding sites, but functional analysis ruled out that these transcriptional regulators or promoter methylation are the cause of HJV downregulation in HCC.
|
21863061 |
2011 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Biallelic inactivating mutations of HNF1A have been frequently identified in hepatocellular adenomas (HCA), rare benign liver tumors usually developed in women under oral contraceptives, and in rare cases of hepatocellular carcinomas developed in non-cirrhotic liver.
|
21975049 |
2011 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver.
|
20041408 |
2010 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Re-expression of HNF-1 in HCC cells reinduced MIA2 in HCC cells to similar levels as found in PHH.
|
17881540 |
2008 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The -803 G > A SNP influenced the transcription efficiency in a hepatocarcinoma cell line as well as the binding efficiency of hepatocyte nuclear factor 1 alpha to the motif.
|
17006670 |
2007 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We identified hepatic nuclear factor 1 (HNF1) as an important liver-specific trans-acting element for the human ACAT2 gene using the human hepatocellular carcinoma cell lines HuH7 and HepG2.
|
15961790 |
2005 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, among these four transcription factors, HNF-4 alpha and HNF-1 alpha expressions showed synchronism and had a close relation with HCC differentiation.
|
12967472 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs.
|
12355088 |
2002 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These findings show that poor histological differentiation of HCC correlates with decreases in the level and activity of HNF-1 alpha proteins.
|
9614379 |
1998 |