Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer.
|
18696045 |
2008 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
|
18758462 |
2008 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer, that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediated through these gene variants.
|
19998368 |
2010 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis.
|
20203524 |
2010 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types.
|
20526366 |
2010 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|
20569440 |
2010 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Some associations appear to be ancestry specific, such as HNF1B, which is associated with prostate cancer in European Americans and Latinos but not in African-Americans.
|
21459759 |
2011 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk.
|
21576123 |
2011 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
As in studies from other populations, our findings indicate that HNF1B is also associated with prostate cancer risk in the Korean population.
|
21982019 |
2011 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk.
|
23193118 |
2012 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
|
23464444 |
2012 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk.
|
23661456 |
2013 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
|
26034056 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies.
|
26214421 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |